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IKK2-IN-4

Name: IKK2-IN-4
Brand: TargetMol
SKU: T36524
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36524Cas No. 354811-10-2

Alias IKK2 Inhibitor IV, 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.

IKK2-IN-4

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Purity: 99.83%

Catalog No. T36524Alias IKK2 Inhibitor IV, 5-Phenyl-2-ureidothiophene-3-carboxylic Acid AmideCas No. 354811-10-2

IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$79	-	In Stock
1 mg	$116	-	In Stock
5 mg	$291	-	In Stock
10 mg	$446	-	In Stock
25 mg	$691	-	In Stock
50 mg	$931	-	In Stock
100 mg	$1,250	-	In Stock
200 mg	$1,670	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

IKK2-IN-4 AI Summary

IKK2-IN-4 exhibits significant bioactivity as an inhibitor of multiple enzymes, including IKK-beta with an IC50 value of approximately 13.0 nM, JAK2 with an IC50 of 61.0 nM, and JAK3 with an IC50 of 2000.0 nM. It demonstrates potential anti-inflammatory and immune response modulation by inhibiting the human IKKbeta enzyme. Additionally, IKK2-IN-4 has shown activity against the SARS-CoV-2 virus, inhibiting the 3CL-Pro protease by 18.53% at a concentration of 20µM and reducing virus-induced cytotoxicity in VERO-6 cells by 0.37% at 10 µM after 48 hours of exposure. For its physicochemical properties, it has a LogD7.4 value of 2.42, indicating its lipophilicity, and an intrinsic clearance rate of 21.0 mL.min-1.g-1 in human liver microsomes, reflecting its metabolic stability. Lastly, IKK2-IN-4 exhibits cytotoxicity against human HepG2 cells, with an IC50 value of 7900.0 nM as determined by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
Targets&IC50	IKKβ:25 nM
Synonyms	IKK2 Inhibitor IV, 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

Chemical Properties

Molecular Weight	261.3
Formula	C₁₂H₁₁N₃O₂S
Cas No.	354811-10-2
Smiles	N(C(N)=O)C=1SC(=CC1C(N)=O)C2=CC=CC=C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (7.65 mM), Sonication is recommended.

DMSO: 30 mg/mL (114.81 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8270 mL	19.1351 mL	38.2702 mL	191.3509 mL
5 mM	0.7654 mL	3.8270 mL	7.6540 mL	38.2702 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3827 mL	1.9135 mL	3.8270 mL	19.1351 mL
20 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5675 mL
50 mM	0.0765 mL	0.3827 mL	0.7654 mL	3.8270 mL
100 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc