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MAGL-IN-5

Name: MAGL-IN-5
Brand: TargetMol
SKU: T9967
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9967Cas No. 359714-55-9

MAGL-IN-5 is a non-selective lipase inhibitor.

MAGL-IN-5

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Purity: 99.73%

Catalog No. T9967Cas No. 359714-55-9

MAGL-IN-5 is a non-selective lipase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	-	In Stock
10 mg	$58	-	In Stock
25 mg	$115	-	In Stock
50 mg	$188	-	In Stock
100 mg	$296	-	In Stock
200 mg	$431	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

MAGL-IN-5 AI Summary

MAGL-IN-5 demonstrates potent inhibitory activity against both human recombinant FAAH (Fatty Acid Amide Hydrolase) and MAGL (Monoacylglycerol Lipase). Specifically, it exhibits an IC50 value of 77.62 nM for FAAH inhibition and an IC50 value of 20.42 nM for MAGL inhibition, with a selectivity ratio favoring MAGL by approximately 3.0. The compound's bioactivity is characterized by its variable potency depending on assay conditions, with IC50 values for MAGL inhibition ranging from 9.0 nM to 480.0 nM and for FAAH inhibition from 14.0 nM to 1,300.0 nM. In addition to its enzyme inhibitory effects, MAGL-IN-5 shows antiproliferative activity against multiple human cancer cell lines, where IC50 values range from 34,000 nM to over 200,000 nM after 96 hours of exposure. The compound has potential therapeutic applications in modulating endocannabinoid signaling pathways due to its high affinity and selective enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

MAGL-IN-5 is a non-selective lipase inhibitor.

Chemical Properties

Molecular Weight	355.34
Formula	C₁₈H₁₇N₃O₅
Cas No.	359714-55-9
Smiles	COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (267.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8142 mL	14.0710 mL	28.1421 mL	140.7103 mL
5 mM	0.5628 mL	2.8142 mL	5.6284 mL	28.1421 mL
10 mM	0.2814 mL	1.4071 mL	2.8142 mL	14.0710 mL
20 mM	0.1407 mL	0.7036 mL	1.4071 mL	7.0355 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL	2.8142 mL
100 mM	0.0281 mL	0.1407 mL	0.2814 mL	1.4071 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc