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Methyl-Hesperidin

Name: Methyl-Hesperidin
Brand: TargetMol
SKU: T0228
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0228Cas No. 11013-97-1

Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.

Methyl-Hesperidin

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Purity: 99.01%

Catalog No. T0228Cas No. 11013-97-1

Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$35	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$59	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.01%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Methyl Hesperidin, a flavanone glycoside (flavonoid) (C28H34O15), is abundant in citrus fruits. Its aglycone form is called hesperetin.

In vivo

Methyl Hesperidin can bind to human serum albumin, with a binding constant between 18 and 34 mM. Long-term carcinogenicity studies have demonstrated that Methyl Hesperidin has no carcinogenic effects on B6C3F1 mice after 96 weeks of feeding. Additionally, Methyl Hesperidin, in conjunction with Hesperidin, can inhibit the phosphorylation of Akt and PKC, resulting in decreased expression of TNF-α-induced VCAM-1.

Chemical Properties

Molecular Weight	624.5871
Formula	C₂₉H₃₆O₁₅
Cas No.	11013-97-1
Smiles	COc1ccc(cc1OC)[C@@H]1CC(=O)c2c(O)cc(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)cc2O1
Relative Density.	1.3090 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: insoluble

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 166.7 mg/mL (266.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6011 mL	8.0053 mL	16.0106 mL	80.0529 mL
5 mM	0.3202 mL	1.6011 mL	3.2021 mL	16.0106 mL
10 mM	0.1601 mL	0.8005 mL	1.6011 mL	8.0053 mL
20 mM	0.0801 mL	0.4003 mL	0.8005 mL	4.0026 mL
50 mM	0.0320 mL	0.1601 mL	0.3202 mL	1.6011 mL
100 mM	0.0160 mL	0.0801 mL	0.1601 mL	0.8005 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc