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ABX-IL8
(Synonyms: Anti-IL-8 antibody, ABXIL8) Copy Product Info
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Synonyms: Anti-IL-8 antibody, ABXIL8
Catalog No. T77465 Copy Product Info
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ABX-IL8 is a humanized antibody targeting IL-8, which interferes with the tubular formation of human umbilical vein endothelial cells, inhibiting angiogenesis, tumor growth, and metastasis in human melanoma.
ABX-IL8
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $183 | - | In Stock | |
| 5 mg | $448 | - | In Stock | |
| 10 mg | $715 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,460 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | ABX-IL8 is a humanized antibody targeting IL-8, which interferes with the tubular formation of human umbilical vein endothelial cells, inhibiting angiogenesis, tumor growth, and metastasis in human melanoma. |
| In vitro | ABX-IL8 (100 μg/ml) did not affect the proliferation of A375SM and TXM-13 melanoma cells, but down-regulated the activity of MMP-2 metalloproteinase, which inhibited the invasion of human melanoma cells. ABX-IL8 (100 μg/ml) directly interferes with tubule formation of human umbilical vein endothelial cells. [1] ABX-IL8 blocking IL-8 significantly inhibited the expression, activity, and transcription of MMP-2 and MMP-9, resulting in reduced invasion through remodeling the basement membrane in vitro. [2] |
| In vivo | In nude mice treated with ABX-IL8 (1 mg/3 times weekly, intrabitoneal injection for 3 weeks) subcutaneously injected with A375SM and TXM-13, results showed that tumor growth of both types of melanoma was significantly inhibited in ABX-IL8-treated mice. [1] |
| Synonyms | Anti-IL-8 antibody, ABXIL8 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-8 Protein at 2 μg/mL can bind ABX-IL8. The EC50 is 0.1472 μg/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CXCL8/IL-8 |
| Molecular Weight | 143.94 kDa |
| Isotype | Human IgG2SA kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: ABX-IL8 in vivo | ABX-IL8 in vitro | ABX-IL8 molecular weight
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