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Amikacin hydrate

Name: Amikacin hydrate
Brand: TargetMol
SKU: T6383
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6383Cas No. 1257517-67-1

Alias BAY 41-6551 hydrate

Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic with bacteriostatic activity used in studies of drug-resistant Mycobacterium tuberculosis infections and Gram-negative bacterial infections, and is commonly used in the clinic for urinary tract infections caused by E. coli.

Amikacin hydrate

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Purity: 99.98%

Catalog No. T6383Alias BAY 41-6551 hydrateCas No. 1257517-67-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$30	In Stock	In Stock
50 mg	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic with bacteriostatic activity used in studies of drug-resistant Mycobacterium tuberculosis infections and Gram-negative bacterial infections, and is commonly used in the clinic for urinary tract infections caused by E. coli.
In vitro	Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
In vivo	In male Fischer 344 rats (40-50-day-old), Amikacin hydrate (320 mg/kg; subcutaneous injection; daily; for 10 days) induces hearing loss in rats[3].
Synonyms	BAY 41-6551 hydrate

Chemical Properties

Molecular Weight	603.623
Formula	C₂₂H₄₃N₅O₁₃.xH₂O
Cas No.	1257517-67-1
Smiles	O([C@H]1[C@H](NC([C@H](CCN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O.O xH2O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 40.00 mg/mL (66.27 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6567 mL	8.2833 mL	16.5666 mL	82.8332 mL
5 mM	0.3313 mL	1.6567 mL	3.3133 mL	16.5666 mL
10 mM	0.1657 mL	0.8283 mL	1.6567 mL	8.2833 mL
20 mM	0.0828 mL	0.4142 mL	0.8283 mL	4.1417 mL
50 mM	0.0331 mL	0.1657 mL	0.3313 mL	1.6567 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc