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Edetic acid
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Catalog No. T20470Cas No. 60-00-4
Alias Ethylenediaminetetraacetic acid, EDTA
Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
Edetic acid
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Purity: 99.71%
Catalog No. T20470Alias Ethylenediaminetetraacetic acid, EDTACas No. 60-00-4
Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 g | $40 | - | In Stock | |
| 10 g | $48 | - | In Stock | |
| 25 g | $81 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction
Edetic acid AI Summary
Edetic acid demonstrates various pharmacological and biological activities. It exhibits significant metal chelating and antioxidant properties, notably reducing Cu2+-amyloid beta-induced H2O2 production and Fe2+-induced hydroxyl radical formation. The compound’s potent inhibition of enzymes, including NDM-1, phosphodiesterase-1, tyrosyl-DNA phosphodiesterase, and snake venom phosphodiesterase, was observed with IC50 values in the nanomolar range. Additionally, Edetic acid shows strong antimicrobial action against methicillin-resistant Staphylococcus aureus and Candida parapsilosis in biofilm models, alongside antispasmodic action by inhibiting acetylcholine-induced contractions in guinea pig ileum.
In biodistribution studies, Edetic acid predominantly accumulates in the liver of normal mice, with significant variations over time: initial high concentrations in the liver sustain and increase from 39.8% to 85.94% over 120 hours. The compound also demonstrates bioactivities such as inhibiting Cu2+-induced amyloid beta aggregation, human DNA binding to HIV-EP1, and both B. atrox and recombinant Pseudomonas aeruginosa MBL enzymes. It has shown efficiency in iron chelation, antioxidant assays, and several enzymatic inhibition tests.
The compound’s human intestinal absorption rate suggests good bioavailability, and it possesses low hepatotoxicity based on DILI predictions. Finally, Edetic acid contributes to outer membrane permeabilization in Escherichia coli and Pseudomonas aeruginosa, effective against biofilm-forming and planktonic bacterial cells, and has shown antiviral potential against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity. |
| Synonyms | Ethylenediaminetetraacetic acid, EDTA |
| Molecular Weight | 292.24 |
| Formula | C10H16N2O8 |
| Cas No. | 60-00-4 |
| Smiles | OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O |
| Relative Density. | 1.46 g/cm3. Temperature:20 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO: Insoluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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