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Inebilizumab is a humanized anti-CD19 monoclonal antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used to treat a range of autoimmune diseases associated with CD19 B cells, such as multiple sclerosis and optic neuromyelitis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 197.00 | |
5 mg | In stock | $ 513.00 | |
10 mg | In stock | $ 826.00 | |
25 mg | In stock | $ 1,260.00 | |
50 mg | In stock | $ 1,680.00 | |
100 mg | In stock | $ 2,290.00 |
Description | Inebilizumab is a humanized anti-CD19 monoclonal antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used to treat a range of autoimmune diseases associated with CD19 B cells, such as multiple sclerosis and optic neuromyelitis. |
In vitro |
Derived from the mouse anti-human mAb HB12b, Inebilizumab had already shown impressive activity in depleting B cells in transgenic mice carrying the human CD19 gene (hCD19 Tg)[1]. Inebilizumab potently depletes CD19-expressing B cells, including primary human B cells, B cell lines derived from multiple tumor types, and neoplastic B cells[1]. Inebilizumab demonstrates equal or better activity than Rituximab in depleting human primary B cells in autologous ADCC assays and shows potent ADCC activity against human in vitro-differentiated and primary plasma cells[1]. |
In vivo | In vivo, Inebilizumab (MEDI-551) (i.v.; once; 0-10 mg/kg) depletes B cells from blood and spleen by mouse macrophages, and it induces phagocytosis of murine B cells ex vivo[2]. |
Synonyms | MEDI 551, MT-0551, 16C4-aFuc, VIB-0551 |
Molecular Weight | N/A |
CAS No. | 1299440-37-1 |
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store at -20°C
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Inebilizumab 1299440-37-1 Others VIB 0551 MEDI 551 MT-0551 MT0551 16C4-aFuc MEDI551 VIB-0551 MT 0551 MEDI-551 VIB0551 inhibitor inhibit