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LY 344864

Name: LY 344864
Brand: TargetMol
SKU: T2344
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2344Cas No. 186544-26-3

Alias LY344864

LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.

LY 344864

🥰Excellent

Catalog No. T2344Alias LY344864Cas No. 186544-26-3

LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	-
5 mg	$55	In Stock	-
10 mg	$89	In Stock	-
25 mg	$169	In Stock	-
50 mg	$312	In Stock	-
100 mg	$555	In Stock	-
1 mL x 10 mM (in DMSO)	$61	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
Targets&IC50	5-HT1A receptor (human):0.530 μM (Ki), α1 adrenoceptor (rat):5.06 μM (Ki), 5-HT2B receptor (human):1.695 μM (Ki), 5-HT1F:6 nM, 5-HT1D receptor (human):0.575 μM (Ki), 5-HT2A receptor (human):3.499 μM (Ki), 5-HT7 receptor (human):4.851 μM (Ki), 5-HT1F receptor (human):0.006 μM (Ki), 5-HT1E receptor (human):1.415 μM (Ki), α2 adrenergic receptor (rat):3.69 μM (Ki), 5-HT1B receptor (human):0.549 μM (Ki), 5-HT3A Receptor (human):3.935 mM (Ki)
Synonyms	LY344864

Chemical Properties

Molecular Weight	351.42
Formula	C₂₁H₂₂FN₃O
Cas No.	186544-26-3
Smiles	Cl.CN(C)[C@@H]1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: >10 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8456 mL	14.2280 mL	28.4560 mL	142.2799 mL
5 mM	0.5691 mL	2.8456 mL	5.6912 mL	28.4560 mL
10 mM	0.2846 mL	1.4228 mL	2.8456 mL	14.2280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc