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Ligustrazine

Name: Ligustrazine
Brand: TargetMol
SKU: T2722
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2722Cas No. 1124-11-4

Alias Tetramethylpyrazine

Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.

Ligustrazine

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Purity: 99.91%

Catalog No. T2722Alias TetramethylpyrazineCas No. 1124-11-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$42	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Color:White

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COA LCMS HNMR

Product Introduction

Ligustrazine AI Summary

Ligustrazine exhibits a diverse range of bioactivities. It stimulates the proliferation rate of human umbilical vascular endothelial cells (HUVECs) by a maximum of 20.66% at a concentration of 0.6 mM. Additionally, it provides protection against hydrogen peroxide-induced damage in various cell types such as ECV304 and SH-SY5Y cells, with EC50 values ranging between 15,180.0 nM to 600,000.0 nM. The compound demonstrates significant anti-platelet activity, inhibiting ADP-induced platelet aggregation in rabbit plasma by up to 42.9%, and also shows antithrombotic activity, with inhibition rates of thrombus formation at 71.2% in Sprague-Dawley rats at 2 mg/kg. It also exhibits neuroprotective activity in various models, including protection against focal cerebral ischemia and spinal cord injury, and has shown neuroprotective effects in assays utilizing t-BHP against rat cerebellar granule neurons. Moreover, Ligustrazine displays antiviral activity against SARS-CoV-2, with inhibition of viral-induced cytotoxicity in VERO-6 and Caco-2 cells, although its IC50 values vary widely from low effectiveness to moderate. The compound also exhibits weak inhibition of human HDAC6 enzyme, antioxidant properties, and moderate solubility and lipophilicity with a LogP of 1.26. Furthermore, it shows anticoagulant activity in rabbit platelet poor plasma and has moderate antitumor activity against various human cancer cell lines, such as K562, A549, HCT116, and U87MG, with IC50 values in the micromolar range. However, it has demonstrated less significant antiproliferative activity against other cell lines, such as Bel7402 and HT-29, indicating varied effectiveness across different cancer types..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
Synonyms	Tetramethylpyrazine

Chemical Properties

Molecular Weight	136.19
Formula	C₈H₁₂N₂
Cas No.	1124-11-4
Smiles	CC1=NC(C)=C(C)N=C1C
Relative Density.	1.08 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 51.05 mg/mL (374.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3427 mL	36.7134 mL	73.4268 mL	367.1342 mL
5 mM	1.4685 mL	7.3427 mL	14.6854 mL	73.4268 mL
10 mM	0.7343 mL	3.6713 mL	7.3427 mL	36.7134 mL
20 mM	0.3671 mL	1.8357 mL	3.6713 mL	18.3567 mL
50 mM	0.1469 mL	0.7343 mL	1.4685 mL	7.3427 mL
100 mM	0.0734 mL	0.3671 mL	0.7343 mL	3.6713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc