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Rasagiline

Name: Rasagiline
Brand: TargetMol
SKU: T1119
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1119Cas No. 136236-51-6

Alias TVP1012, AGN1135

Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.

Rasagiline

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Purity: 99.87%

Catalog No. T1119Alias TVP1012, AGN1135Cas No. 136236-51-6

Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	-	In Stock
50 mg	$48	-	In Stock
100 mg	$75	-	In Stock
1 mL x 10 mM (in DMSO)	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Color:Yellow

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COA HNMR LCMS

Product Introduction

Rasagiline AI Summary

Rasagiline exhibits potent inhibitory activity against both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) enzymes, showing a notably lower IC50 value for MAO-B (ranging from 14.0 nM to 83.0 nM) compared to MAO-A (ranging from 410.0 nM to 70140.0 nM). The compound demonstrates selectivity for MAO-B over MAO-A, with selectivity indices indicating a strong preference for MAO-B inhibition. Binding assays reveal a high affinity for MAO-B, supported by various Ki values, ranging from 7.6 nM to 700.0 nM. Moreover, Rasagiline irreversibly inhibits both enzymes, leading to enzyme inactivation and decay. In addition to its effects on MAO enzymes, the compound shows diverse bioactivities, including neuroprotective effects in cellular models, antiviral activity against SARS-CoV-2, and potential for inducing drug-induced liver injury. It also exhibits cytotoxicity in some cell types and possesses binding affinity to a variety of receptors and enzymes. This multifaceted bioactivity profile suggests its potential therapeutic applications in conditions like neurological disorders and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
Targets&IC50	MAO-A:412 nM, MAO-B:4.43 nM
Synonyms	TVP1012, AGN1135

Chemical Properties

Molecular Weight	171.24
Formula	C₁₂H₁₃N
Cas No.	136236-51-6
Smiles	C#CCN[C@@H]1CCC2=C1C=CC=C2
Relative Density.	1.05 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 23.4 mM, Sonication is recommended.

DMSO: 50 mg/mL (291.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8398 mL	29.1988 mL	58.3976 mL	291.9879 mL
5 mM	1.1680 mL	5.8398 mL	11.6795 mL	58.3976 mL
10 mM	0.5840 mL	2.9199 mL	5.8398 mL	29.1988 mL
20 mM	0.2920 mL	1.4599 mL	2.9199 mL	14.5994 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1168 mL	0.5840 mL	1.1680 mL	5.8398 mL
100 mM	0.0584 mL	0.2920 mL	0.5840 mL	2.9199 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc