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Anti-ALOX15 Antibody (8G848)
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Catalog No. TMAB-02448
Anti-ALOX15 Antibody (8G848) is a Rabbit antibody targeting ALOX15. Anti-ALOX15 Antibody (8G848) can be used in IHC-P,IHC-Fr,IF.
Anti-ALOX15 Antibody (8G848)
Anti-ALOX15 Antibody (8G848)
😃Good
Catalog No. TMAB-02448
Anti-ALOX15 Antibody (8G848) is a Rabbit antibody targeting ALOX15. Anti-ALOX15 Antibody (8G848) can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ALOX15 Antibody (8G848) is a Rabbit antibody targeting ALOX15. Anti-ALOX15 Antibody (8G848) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 8G848 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Tissue Specificity | Skeletal muscle and brain (cerebellum and hippocampus). |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation. |
| Immunogen | KLH conjugated synthetic peptide: human ALOX15 |
| Antigen Species | Human |
| Gene Name | ALOX15 |
| Gene ID | |
| Protein Name | Polyunsaturated fatty acid lipoxygenase ALOX15 |
| Uniprot ID | |
| Function | Oxygenase and 14,15-leukotriene A4 synthase activity. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid. |
| Molecular Weight | Theoretical: 73 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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