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Anti-PHF2 Polyclonal Antibody

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Catalog No. TMAB-10266

Anti-PHF2 Polyclonal Antibody is a Rabbit antibody targeting PHF2. Anti-PHF2 Polyclonal Antibody can be used in IHC-P,WB,IHC-Fr,IF.

Anti-PHF2 Polyclonal Antibody

Anti-PHF2 Polyclonal Antibody

😃Good
Catalog No. TMAB-10266
Anti-PHF2 Polyclonal Antibody is a Rabbit antibody targeting PHF2. Anti-PHF2 Polyclonal Antibody can be used in IHC-P,WB,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PHF2 Polyclonal Antibody is a Rabbit antibody targeting PHF2. Anti-PHF2 Polyclonal Antibody can be used in IHC-P,WB,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep)
Application
IHC-P
WB
IHC-Fr
IF
Recommended Dose
IHC-P: 1:100-500; WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus, nucleolus.
Tissue SpecificityWidely expressed, including in liver (at protein level).
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThis gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
Recombinant Protein: human PHF2 protein
Antigen Species
Human
Gene Name
PHF2
Gene ID
5253
Protein Name
Lysine-specific demethylase PHF2
Uniprot ID
O75151
Function
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Chemical Properties
Molecular WeightTheoretical: 121 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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