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Acelarin

Name: Acelarin
Brand: TargetMol
SKU: T4060
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4060Cas No. 840506-29-8

Alias NUC-1031

Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.

Acelarin

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Purity: 99.26%

Catalog No. T4060Alias NUC-1031Cas No. 840506-29-8

Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.

Pack Size	Price	Availability
1 mg	$38	In Stock
2 mg	$54	In Stock
5 mg	$89	In Stock
10 mg	$147	In Stock
25 mg	$288	In Stock
50 mg	$513	In Stock
100 mg	$746	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:99.26%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.
Targets&IC50	DNA synthesis:EC50 : 0.2 nM
Synonyms	NUC-1031

Chemical Properties

Molecular Weight	580.47
Formula	C₂₅H₂₇F₂N₄O₈P
Cas No.	840506-29-8
Smiles	FC1(F)[C@@H](O[C@H](COP(OC2=CC=CC=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)[C@H]1O)N4C(=O)N=C(N)C=C4
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (94.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7227 mL	8.6137 mL	17.2274 mL	86.1371 mL
5 mM	0.3445 mL	1.7227 mL	3.4455 mL	17.2274 mL
10 mM	0.1723 mL	0.8614 mL	1.7227 mL	8.6137 mL
20 mM	0.0861 mL	0.4307 mL	0.8614 mL	4.3069 mL
50 mM	0.0345 mL	0.1723 mL	0.3445 mL	1.7227 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc