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Anti-CD146/MCAM Antibody (5R295) (Synonyms: MUC18, melanoma cell adhesion molecule, CD146)
Catalog No. TMAY-03463 Copy Product Info
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Anti-CD146/MCAM Antibody (5R295) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (5R295) can be used in IHC-P.
Anti-CD146/MCAM Antibody (5R295)
Copy Product Info🥰Excellent
Catalog No. TMAY-03463
Synonyms MUC18, melanoma cell adhesion molecule, CD146
Anti-CD146/MCAM Antibody (5R295) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (5R295) can be used in IHC-P.
Anti-CD146/MCAM Antibody
(5R295)
(5R295)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $270 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CD146/MCAM Antibody (5R295) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (5R295) can be used in IHC-P. |
| Synonyms | MUC18, melanoma cell adhesion molecule, CD146 |
| Ig Type | Rabbit IgG |
| Clone | 5R295 |
| Reactivity | Mouse |
| Specificity | Mouse CD146/MCAM |
| Verified Activity | Immunochemical staining of mouse MCAM in mouse liver with rabbit monoclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Application | |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD146 / MCAM (rM CD146 / MCAM; TMPY-02502; Q8R2Y2-1; Met1-Val563). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse CD146 / MCAM Protein (TMPY-02502) |
| Antigen Species | Mouse |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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