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kaempferide (Alias: Kaempferol 4'-O-methyl ether, Kaempferol 4'-methyl ether, 4'-O-Methylkaempferol, 4'-Me...)

Name: kaempferide
Brand: TargetMol
SKU: T3806
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3806 Copy Product Info

Purity: 99.66%

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kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.

kaempferide

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Catalog No. T3806

Alias Kaempferol 4'-O-methyl ether, Kaempferol 4'-methyl ether, 4'-O-Methylkaempferol, 4'-Methylkaempferol

Cas No. 491-54-3

Pack Size	Price	USA Stock	Global Stock
10 mg	$35	In Stock	In Stock
25 mg	$70	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$179	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.66%

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

kaempferide AI Summary

kaempferide exhibits a diverse range of biological activities and affinities. It demonstrates binding affinity to the nucleotide-binding domain (NBD2) of P-Glycoprotein with a dissociation constant (Kd) of approximately 4466-5000 nM and shows a high percentage of maximal quenching fluorescence for binding analysis. It exhibits weak in vitro antibacterial activity, with minimum inhibitory concentrations (MIC) greater than 125.0 µg/mL against various bacterial strains, and inhibits DNA-gyrase supercoiling with an IC50 greater than 500.0 µg/mL. The compound shows significant antiproliferative effects on the human colonic cell line (HT-29), an IC50 of 6.0 nM against CYP1B1, and weaker effects against CYP1A1 and CYP1A2. It also inhibits mitochondrial NADH oxidase and succinoxidase significantly and shows activity against mitochondrial ATPase. Additionally, kaempferide exhibits cytotoxicity against several cell lines (e.g., KB, HT1080, HCT116) at varying concentrations and demonstrates antiangiogenic and osteogenic differentiation effects in human mesenchymal stem cells. It displays inhibitory effects on procoagulant activity, melanogenesis, and cys-leukotriene release, among others. The compound also shows activity against viral targets, including SARS-CoV-2, and has demonstrated antimycobacterial activity. Despite its broad spectrum of bioactivity, the effective concentrations and inhibitory potencies vary widely across different biological targets and assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activation.
Synonyms	Kaempferol 4'-O-methyl ether, Kaempferol 4'-methyl ether, 4'-O-Methylkaempferol, 4'-Methylkaempferol

Chemical Properties

Molecular Weight	300.26
Formula	C₁₆H₁₂O₆
Cas No.	491-54-3
Smiles	COc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Relative Density.	1.538 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (199.83 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3304 mL	16.6522 mL	33.3045 mL	166.5223 mL
5 mM	0.6661 mL	3.3304 mL	6.6609 mL	33.3045 mL
10 mM	0.3330 mL	1.6652 mL	3.3304 mL	16.6522 mL
20 mM	0.1665 mL	0.8326 mL	1.6652 mL	8.3261 mL
50 mM	0.0666 mL	0.3330 mL	0.6661 mL	3.3304 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6652 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc