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Genkwanin

Name: Genkwanin
Brand: TargetMol
SKU: T6S0095
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S0095Cas No. 437-64-9

Alias Puddumetin, Apigenin 7-methyl ether, 7-O-Methylapigenin

1. Genkwanin (Apigenin 7-methyl ether) exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diffusion and multidrug resistance protein (MDR)-mediated efflux mechanisms.

Genkwanin

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Purity: 99.31%

Catalog No. T6S0095Alias Puddumetin, Apigenin 7-methyl ether, 7-O-MethylapigeninCas No. 437-64-9

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$52	In Stock	In Stock
50 mg	$85	In Stock	In Stock
100 mg	$139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.31%

Color:White to Yellow

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COA HPLC

Product Introduction

Genkwanin AI Summary

Genkwanin possesses a range of bioactivities and selective inhibitory properties. It has antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 with an IC50 of 111,000.0 nM, and it demonstrates inhibitory action against HIV1 replication and reverse transcriptase with EC50 greater than 100,000.0 nM and IC50 greater than 200.0 µg/mL, respectively. The compound also inhibits bovine thymus p56LCK-catalyzed phosphorylation of angiotensin 1 (IC50 of 80.0 µg/mL) and shows cytotoxic activities against multiple human cell lines, such as TERT-RPE1 (ED50 of 3.9 µg/mL), A2780 (IC50 > 20.0 µg/mL), and KB cells (IC50 of 8.7 and 16.4 µg/mL). It selectively inhibits Trypanosoma cruzi trans-sialidase mutant with an IC50 of 140,000.0 nM while having limited effect on human Neu2 (IC50 > 1,000,000.0 nM). Additionally, the compound exhibits activity toward CYP1A1 and CYP1B1 enzymes with a Ki value greater than 2340.0 nM and substantial activation in CYP1 expressing MDA-MB-468 cells. It inhibits OATP1B1 and OATP1B3 functions with over 100% inhibition in the uptake of sodium fluorescein at 10 µM. Furthermore, Genkwanin hinders MNK2 kinase activity (IC50 of 979.0 nM) and FLT3 activity against residues 564 to 958 (IC50 of 1700.0 nM) and shows significant cytotoxicity in several cell lines, such as A549, SK-MEL-2, SKOV3, XF498, and HCT15, with IC50 values of 0.4 µg/mL and moderate antioxidant activity against ONOO with IC50 of 1010.0 nM. It demonstrates selectivity for Trypanosoma cruzi and minimal cytotoxicity in certain human cells, indicating its potential for varied therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Genkwanin (Apigenin 7-methyl ether) exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diffusion and multidrug resistance protein (MDR)-mediated efflux mechanisms.
Synonyms	Puddumetin, Apigenin 7-methyl ether, 7-O-Methylapigenin

Chemical Properties

Molecular Weight	284.26
Formula	C₁₆H₁₂O₅
Cas No.	437-64-9
Smiles	COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)cc1
Relative Density.	1.42g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

H2O: < 1 mg/mL (insoluble)

DMSO: 64.375 mg/mL (226.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5179 mL	17.5895 mL	35.1791 mL	175.8953 mL
5 mM	0.7036 mL	3.5179 mL	7.0358 mL	35.1791 mL
10 mM	0.3518 mL	1.7590 mL	3.5179 mL	17.5895 mL
20 mM	0.1759 mL	0.8795 mL	1.7590 mL	8.7948 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL	3.5179 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	1.7590 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc