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LED209
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Catalog No. T2703Cas No. 245342-14-7
LED209, a specific inhibitor of quorum sensor QseC of GNB, can generate a multifunctional agent PAMAM-LED209.
LED209
Copy Product Info🥰Excellent
Purity: 97.35%
Catalog No. T2703Cas No. 245342-14-7
LED209, a specific inhibitor of quorum sensor QseC of GNB, can generate a multifunctional agent PAMAM-LED209.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $39 | In Stock | In Stock | |
| 50 mg | $76 | In Stock | In Stock | |
| 100 mg | $113 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.35%
Color:White
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Product Introduction
LED209 AI Summary
LED209 exhibits antibacterial activity specifically against Salmonella Typhimurium and Francisella tularensis in mouse models, showing a reduction in bacterial CFU in spleen and liver, along with improved survival rates following bacterial challenges. It has demonstrated oral bioavailability and clearance in these models. Although it impacts various blood parameters like neutrophil, lymphocyte, and monocyte counts, as well as cholesterol, glucose, and urea nitrogen levels, the compound shows no significant bioactivity across a range of tested assays against Candida albicans, Cryptococcus neoformans, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus, with high MIC values above 20000.0 nM. Additionally, LED209 exhibited no haemolytic activity on human red blood cells and low cytotoxicity against HEK293 cells, with an HC10 greater than 20.0 uM and a CC50 greater than 20000.0 nM, respectively..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LED209, a specific inhibitor of quorum sensor QseC of GNB, can generate a multifunctional agent PAMAM-LED209. |
| Molecular Weight | 383.49 |
| Formula | C19H17N3O2S2 |
| Cas No. | 245342-14-7 |
| Smiles | O=S(=O)(Nc1ccccc1)c1ccc(NC(=S)Nc2ccccc2)cc1 |
| Relative Density. | 1.437 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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