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Anti-GM-CSF/CSF2 Antibody (6J807)

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Catalog No. TMAY-00085
Alias GM-CSF, GMCSF, CSF2, colony stimulating factor 2 (granulocyte-macrophage)

Anti-GM-CSF/CSF2 Antibody (6J807) is a Rabbit antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (6J807) can be used in ELISA.

Anti-GM-CSF/CSF2 Antibody (6J807)

Anti-GM-CSF/CSF2 Antibody (6J807)

😃Good
Catalog No. TMAY-00085Alias GM-CSF, GMCSF, CSF2, colony stimulating factor 2 (granulocyte-macrophage)
Anti-GM-CSF/CSF2 Antibody (6J807) is a Rabbit antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (6J807) can be used in ELISA.
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20 μL$94 7-10 days
100 μL$270 7-10 days
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Product Introduction

Bioactivity
Description
Anti-GM-CSF/CSF2 Antibody (6J807) is a Rabbit antibody targeting GM-CSF/CSF2. Anti-GM-CSF/CSF2 Antibody (6J807) can be used in ELISA.
AliasGM-CSF, GMCSF, CSF2, colony stimulating factor 2 (granulocyte-macrophage)
Ig Type
Monoclonal Rabbit IgG
Clone
6J807
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human GM-CSF / CSF2 (rh GM-CSF / CSF2; TMPY-02466; NP_000749.2; Ala18-Glu144).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundGranulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF stimulates the differentiation of hematopoietic progenitors to monocytes and neutrophils, and reduces the risk for febrile neutropenia in cancer patients. GM-CSF also has been shown to induce the differentiation of myeloid dendritic cells (DCs) that promote the development of T-helper type 1 (cellular) immune responses in cognate T cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target. GM-CSF has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human GM-CSF / CSF2 protein (TMPY-02466)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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