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Isogambogic acid
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Catalog No. TN6559Cas No. 149655-52-7
Isogambogic acid shows cytotoxic activiity against KB and drug-resistant KB-V1 cell lines.
Isogambogic acid
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Catalog No. TN6559Cas No. 149655-52-7
Isogambogic acid shows cytotoxic activiity against KB and drug-resistant KB-V1 cell lines.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $550 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Isogambogic acid shows cytotoxic activiity against KB and drug-resistant KB-V1 cell lines. |
| In vitro | METHODS AND RESULTS: Three xanthone derivatives, gambogic acid, Isogambogic acid and isomorellinol, were isolated from the dried latex of Garcinia hanburyi. Two of them, Isogambogic acid and isomorellinol, are new. Determinations of the structures and stereochemistry were achieved independently by a series of NMR experiments including COSY, ROESY, HMQC, HMBC and selective INEPT. Isolation of isomorellinol from G. hanburyi provided important chemical evidence to link this species to G. morella. The presence of gambogic acid and Isogambogic acid, however, demonstrated the difference between these two species. CONCLUSIONS: Cytotoxic evaluation of these isolates revealed that all three were active against KB and drug-resistant KB-V1 cell lines. |
| Molecular Weight | 628.762 |
| Formula | C38H44O8 |
| Cas No. | 149655-52-7 |
| Smiles | [H][C@@]12[#6]C3([H])[#6]=[#6]4-[#6](=O)-c5c(-[#8])c6-[#6]=[#6][C@@]([#6])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[#8]-c6c(-[#6]\[#6]=[#6](\[#6])-[#6])c5-[#8][C@@]14[C@@]([#6]\[#6]=[#6](/[#6])-[#6](-[#8])=O)([#8]C2([#6])[#6])[#6]3=O |c:13,t:5,TLB:35:34:6.5:2.1,32:33:3.46.2:43.42,5:3:33:43.42,42:34:6.5:2.1,THB:6:33:3.46.2:43.42,43:1:6.5:34.46| |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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