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2'-Fluoro-2'-Deoxyadenosine

🥰Excellent
Catalog No. T9727Cas No. 64183-27-3

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

2'-Fluoro-2'-Deoxyadenosine

2'-Fluoro-2'-Deoxyadenosine

🥰Excellent
Purity: 99.95%
Catalog No. T9727Cas No. 64183-27-3
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$29In StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.95%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.
Chemical Properties
Molecular Weight269.23
FormulaC10H12FN5O3
Cas No.64183-27-3
SmilesNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F
Relative Density.2.01 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (185.71 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.43 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7143 mL18.5715 mL37.1430 mL185.7148 mL
5 mM0.7429 mL3.7143 mL7.4286 mL37.1430 mL
10 mM0.3714 mL1.8571 mL3.7143 mL18.5715 mL
20 mM0.1857 mL0.9286 mL1.8571 mL9.2857 mL
50 mM0.0743 mL0.3714 mL0.7429 mL3.7143 mL
100 mM0.0371 mL0.1857 mL0.3714 mL1.8571 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tumorpurine nucleoside phosphorylaseoligonucleotideNucleosideAntimetaboliteNucleoside Antimetabolite/AnalogNucleoside AntimetaboliteInhibitorinhibitFAdeAnalog2'Fluoro2'Deoxyadenosine2'-Fluoro-2'-Deoxyadenosine2' Fluoro 2' Deoxyadenosine
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