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Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody 2
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Catalog No. TMAC-02814
Alias v-rel avian reticuloendotheliosis viral oncogene homolog A, p-NF-kB p65 (Ser536), p-NF-kB p65 (S536), p65, NFKB3, NF-kB p65 (p-Ser536), NF-kB p65 (p-S536)
Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NF-kB p65 (Ser536). Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody can be used in IF,IHC,WB.
Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody 2
Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody 2
😃Good
Catalog No. TMAC-02814Alias v-rel avian reticuloendotheliosis viral oncogene homolog A, p-NF-kB p65 (Ser536), p-NF-kB p65 (S536), p65, NFKB3, NF-kB p65 (p-Ser536), NF-kB p65 (p-S536)
Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NF-kB p65 (Ser536). Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody can be used in IF,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $316 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NF-kB p65 (Ser536). Anti-Phospho-NF-kB p65 (Ser536) Polyclonal Antibody can be used in IF,IHC,WB. |
| Synonyms | v-rel avian reticuloendotheliosis viral oncogene homolog A, p-NF-kB p65 (Ser536), p-NF-kB p65 (S536), p65, NFKB3, NF-kB p65 (p-Ser536), NF-kB p65 (p-S536) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from HepG2 and HL60 cells untreated or treated with TNF using NFkB-p65 (Phospho-Ser536) Antibody TMAC-02814. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814 (left) or the same antibody preincubated with blocking peptide (right). 3. Immunofluorescence staining of methanol-fixed Hela cells using NFkB-p65 (Phospho-Ser536) Antibody TMAC-02814. 4. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814. 5. Immunohistochemical analysis of paraffin-embedded human Lung carcinoma tissue using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814. 6. Immunofluorescence staining of methanol-fixed MEF cells using NFκB-p65 (Phospho-Ser536) Antibody TMAC-02814.       |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of serine 536 (F-S-S(p)-I-A) derived from Human NFkB-p65 |
| Antigen Species | human |
| Uniprot ID |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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