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TargetMol | Compound Library

Glycometabolism Compound Library

Catalog No. L2520

Glucose and glycogen are initial materials involved in the glycometabolism. A chronically irregular diet could result in the disorders of glycometabolism, which was manifested by the gradual deterioration of glucose tolerance over time, leading to the increased fasting blood glucose or impaired glucose tolerance. The clinical manifestations of glycometabolism-related disorder are hyperglycemia or hypoglycemia, which might eventually contribute to some serious diseases, such as diabetes, G6PD deficiency, obesity and malnutrition. In addition, favored glycolysis under aerobic conditions (aerobic glycolysis), or the Warburg effect, the transition from oxidative phosphorylation to glycolysis, accompanied by the accumulation of lactate by-products in the surrounding microenvironment and 20-30 times faster rate of glucose metabolism than the complete oxidation of glucose in the mitochondria, represents the most typical change observed in the metabolism of cancer cells. Therefore, a key to selective killing of cancer cells lies in their dependence on glycolysis. Targeting tumor cell metabolism has become a successful approach to the prevention or treatment of cancer. Most efforts have focused on the use of small molecules to inhibit the function of metabolic enzymes, which has been comprehensively reviewed elsewhere. Increasing evidence supports many glycolytic enzymes and transporters as candidates for cancer treatment. TargetMol’s Glycometabolism Compound Library collects 702 glycometabolism-related compounds, targeting GLUTs, Hexokinase(HK), Pyruvate Kinase(PK ), phosphofructokinase(PFK), IDH1/2, LDH, AMPK, etc. It is a powerful tool for research in glycometabolism-related disorders and cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2520

Glycometabolism Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • 702 glycometabolism-related comounds, can be used for HTS and HCT;
  • Targets contain GLUTs、Hexokinase(HK)、Pyruvate Kinase(PK)、phosphofructokinase(PFK)、IDH1/2、LDH、AMPK, etc.;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.
  • All compounds are in stock.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Apoptosis
Autophagy
PI3K
Phosphatase
PPAR
mTOR
AMPK
Akt
GSK-3
Endogenous Metabolite
Dehydrogenase
Antibacterial
Carbonic Anhydrase
DNA-PK
Glucosidase
HIF
p53
HIF/HIF Prolyl-Hydroxylase
NF-κB
Parasite
ATM/ATR
S6 Kinase
CDK
IGF-1R
Mitochondrial Metabolism
PDK
Antibiotic
Glucokinase
DPP-4
Proteasome
Ferroptosis
COX
transporter
Glucocorticoid Receptor
Reactive Oxygen Species
SGLT
Reductase
Antifungal
PKC
E1/E2/E3 Enzyme
Isocitrate Dehydrogenase (IDH)
Influenza Virus
HIV Protease
Src
Mitophagy
Wnt/beta-catenin
P450
Potassium Channel
Tyrosinase
PKM
Virus Protease
PKA
PARP
VEGFR
ERK
SGK
Mdm2
NADPH
NAMPT
Calcium Channel
ROCK
HSV
MMP
TNF
Histone Methyltransferase
PERK
Chk
Lipoxygenase
Casein Kinase
STAT
MEK
ATPase
JNK
PDE
PDGFR
Interleukin
EGFR
AChE
PI4K
FGFR
FLT
Chloride channel
p38 MAPK
Estrogen/progestogen Receptor
c-Met/HGFR
TRP/TRPV Channel
Adrenergic Receptor
Aryl Hydrocarbon Receptor
SIK
Phosphorylase
Hexokinase
IL Receptor
PTEN
Androgen Receptor
Sirtuin
ALK
Sodium Channel
NADPH-oxidase
Integrin
Antioxidant
Estrogen Receptor/ERR
Tyrosine Kinases
Serine Protease
Amylase
Topoisomerase
Bcr-Abl
Gamma-secretase
Raf
BCL
PAK
PGC-1α
Aurora Kinase
GluR
Epigenetic Reader Domain
TGF-beta/Smad
ATP Citrate Lyase
DNA/RNA Synthesis
LRRK2
MELK
Beta Amyloid
HDAC
c-Fms
GABA Receptor
c-RET
AChR
Syk
Anti-infection
Microtubule Associated
FAK
AhR
Proton pump
NOS
DHFR
HCV Protease
YAP
Arginase
DNA Alkylator/Crosslinker
Adenosine Receptor
BACE
Histone Demethylase
Glutathione Peroxidase
Progesterone Receptor
ABC
MRP
HBV
Hck
Serine/threonin kinase
cell cycle arrest
Cysteine Protease
PYK2
Glutaminase
CSF-1R
Immunology/Inflammation related
iGluR
Myosin
Drug Metabolite
Glucagon Receptor
ROS
Guanylate cyclase
Fatty Acid Synthase
JAK
DNA Alkylation
Bombesin Receptor
Hedgehog/Smoothened
CaMK
Beta-Secretase
MAPK
HSP
Prostaglandin Receptor
Trk receptor
Nrf2
IκB/IKK
Reverse Transcriptase
Retinoid Receptor
Ligand for E3 Ligase
Phospholipase
PLK
Adenosine deaminase
Complement System
c-Kit
Thrombin
MLK
S1P Receptor

Keywords