Glycometabolism Compound Library

Catalog No. L2520

Library Compound List Excel SDF

Glucose and glycogen are initial materials involved in the glycometabolism. A chronically irregular diet could result in the disorders of glycometabolism, which was manifested by the gradual deterioration of glucose tolerance over time, leading to the increased fasting blood glucose or impaired glucose tolerance. The clinical manifestations of glycometabolism-related disorder are hyperglycemia or hypoglycemia, which might eventually contribute to some serious diseases, such as diabetes, G6PD deficiency, obesity and malnutrition.

In addition, favored glycolysis under aerobic conditions (aerobic glycolysis), or the Warburg effect, the transition from oxidative phosphorylation to glycolysis, accompanied by the accumulation of lactate by-products in the surrounding microenvironment and 20-30 times faster rate of glucose metabolism than the complete oxidation of glucose in the mitochondria, represents the most typical change observed in the metabolism of cancer cells. Therefore, a key to selective killing of cancer cells lies in their dependence on glycolysis. Targeting tumor cell metabolism has become a successful approach to the prevention or treatment of cancer. Most efforts have focused on the use of small molecules to inhibit the function of metabolic enzymes, which has been comprehensively reviewed elsewhere. Increasing evidence supports many glycolytic enzymes and transporters as candidates for cancer treatment.

TargetMol’s Glycometabolism Compound Library collects 708 glycometabolism-related compounds, targeting GLUTs, Hexokinase（HK）, Pyruvate Kinase（PK ）, phosphofructokinase（PFK）, IDH1/2, LDH, AMPK, etc. It is a powerful tool for research in glycometabolism-related disorders and cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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Product Description

708 glycometabolism-related comounds, can be used for HTS and HCT;
Targets contain GLUTs、Hexokinase（HK）、Pyruvate Kinase（PK）、phosphofructokinase（PFK）、IDH1/2、LDH、AMPK, etc.;
Detailed compound information with structure, target, and biological activity description;
NMR and HPLC/LCMS validated to ensure high purity and quality.
All compounds are in stock.

Library Customization

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Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

Apoptosis (117)

Autophagy (116)

PI3K (107)

Phosphatase (76)

PPAR (62)

mTOR (60)

AMPK (51)

Akt (44)

Glucokinase (40)

Endogenous Metabolite (36)

GSK-3 (35)

Dehydrogenase (32)

Antibacterial (30)

DNA-PK (25)

Carbonic Anhydrase (25)

p53 (23)

HIF/HIF Prolyl-Hydroxylase (21)

HIF (21)

NF-κB (19)

S6 Kinase (19)

Parasite (18)

ATM/ATR (18)

CDK (17)

IGF-1R (17)

PDK (16)

Antibiotic (16)

Mitochondrial Metabolism (16)

DPP-4 (15)

Glucocorticoid Receptor (14)

Ferroptosis (14)

Proteasome (14)

Reactive Oxygen Species (14)

COX (14)

SGLT (14)

transporter (14)

Reductase (11)

PKC (10)

Antifungal (10)

HIV Protease (9)

E1/E2/E3 Enzyme (9)

Isocitrate Dehydrogenase (IDH) (9)

Influenza Virus (9)

Wnt/beta-catenin (8)

P450 (8)

Mitophagy (8)

Tyrosinase (8)

Potassium Channel (8)

PKM (8)

Src (8)

VEGFR (7)

TNF (7)

PARP (7)

ERK (7)

PKA (7)

Virus Protease (7)

SGK (7)

NAMPT (6)

NADPH (6)

Calcium Channel (6)

MMP (6)

Mdm2 (6)

HSV (6)

ROCK (6)

PERK (5)

Chk (5)

MEK (5)

Lipoxygenase (5)

Histone Methyltransferase (5)

Casein Kinase (5)

STAT (5)

Interleukin (4)

FLT (4)

EGFR (4)

PDE (4)

PDGFR (4)

AChE (4)

FGFR (4)

ATPase (4)

JNK (4)

PI4K (4)

ALK (3)

Androgen Receptor (3)

p38 MAPK (3)

Sodium Channel (3)

NADPH-oxidase (3)

PTEN (3)

Chloride channel (3)

IL Receptor (3)

SIK (3)

Estrogen/progestogen Receptor (3)

c-Met/HGFR (3)

Adrenergic Receptor (3)

Aryl Hydrocarbon Receptor (3)

Hexokinase (3)

Sirtuin (3)

TRP/TRPV Channel (3)

Phosphorylase (3)

AhR (2)

Beta Amyloid (2)

AChR (2)

DNA/RNA Synthesis (2)

Epigenetic Reader Domain (2)

c-Fms (2)

Estrogen Receptor/ERR (2)

Anti-infection (2)

PAK (2)

BCL (2)

Antioxidant (2)

Integrin (2)

GluR (2)

Gamma-secretase (2)

Aurora Kinase (2)

Serine Protease (2)

HDAC (2)

GABA Receptor (2)

ATP Citrate Lyase (2)

Topoisomerase (2)

Microtubule Associated (2)

Tyrosine Kinases (2)

TGF-beta/Smad (2)

c-RET (2)

Raf (2)

MELK (2)

Bcr-Abl (2)

LRRK2 (2)

FAK (2)

Syk (2)

Trk receptor (1)

Proton pump (1)

Serine/threonin kinase (1)

Thrombin (1)

S1P Receptor (1)

Progesterone Receptor (1)

Prostaglandin Receptor (1)

Reverse Transcriptase (1)

PYK2 (1)

Retinoid Receptor (1)

ROS (1)

ABC (1)

PLK (1)

cell cycle arrest (1)

DNA Alkylator/Crosslinker (1)

DNA Alkylation (1)

DHFR (1)

Cysteine Protease (1)

CSF-1R (1)

Complement System (1)

c-Kit (1)

CaMK (1)

Fatty Acid Synthase (1)

Bombesin Receptor (1)

Beta-Secretase (1)

BACE (1)

Arginase (1)

Adenosine Receptor (1)

Adenosine deaminase (1)

ADC Cytotoxin (1)

Drug Metabolite (1)

Glucagon Receptor (1)

Phospholipase (1)

Immunology/Inflammation related (1)

NOS (1)

Myosin (1)

MRP (1)

MLK (1)

MAPK (1)

JAK (1)

IκB/IKK (1)

iGluR (1)

Glutaminase (1)

HSP (1)

Histone Demethylase (1)

Hedgehog/Smoothened (1)

HCV Protease (1)

Hck (1)

HBV (1)

Guanylate cyclase (1)

Glutathione Peroxidase (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty