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Leachianone A

Name: Leachianone A
Brand: TargetMol
SKU: TN1856
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1856Cas No. 97938-31-3

Alias Isokurarinone

Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.

Leachianone A

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Purity: 99.79%

Catalog No. TN1856Alias IsokurarinoneCas No. 97938-31-3

Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$318	In Stock	In Stock
25 mg	$533	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$148	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.79%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
Targets&IC50	HepG2 cells:3.4microg/ml
In vitro	In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1]
In vivo	Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1].
Synonyms	Isokurarinone

Chemical Properties

Molecular Weight	438.51
Formula	C₂₆H₃₀O₆
Cas No.	97938-31-3
Smiles	COc1cc(O)ccc1[C@@H]1CC(=O)c2c(O)cc(O)c(C[C@@H](CC=C(C)C)C(C)=C)c2O1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (171.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2804 mL	11.4022 mL	22.8045 mL	114.0225 mL
5 mM	0.4561 mL	2.2804 mL	4.5609 mL	22.8045 mL
10 mM	0.2280 mL	1.1402 mL	2.2804 mL	11.4022 mL
20 mM	0.1140 mL	0.5701 mL	1.1402 mL	5.7011 mL
50 mM	0.0456 mL	0.2280 mL	0.4561 mL	2.2804 mL
100 mM	0.0228 mL	0.1140 mL	0.2280 mL	1.1402 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc