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OXSI-2

Name: OXSI-2
Brand: TargetMol
SKU: T28281
Rating: 4.5 (1 reviews)

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Catalog No. T28281Cas No. 622387-85-3

Alias Syk Inhibitor, OXSI 2

OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.

OXSI-2

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Catalog No. T28281Alias Syk Inhibitor, OXSI 2Cas No. 622387-85-3

OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.

Pack Size	Price	Availability
500 μg	$113	35 days
1 mg	$196	35 days
10 mg	$667	35 days

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Product Introduction

Bioactivity

Description	OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.
Targets&IC50	Syk:14 nM, Syk:313 nM(EC50)
In vitro	OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM. OXSI-2 (2 μM) completely shape change and blocks GPVI-mediated dense granule release[2]. OXSI-2 (2 μM) inhibits pyroptotic cell death, inflammasome assembly, caspase-1 activation, IL-1β processing and release and mitochondrial ROS generation[3].
Synonyms	Syk Inhibitor, OXSI 2

Chemical Properties

Molecular Weight	353.39
Formula	C₁₈H₁₅N₃O₃S
Cas No.	622387-85-3
Smiles	C(=C1C=2C(NC1=O)=CC=C(S(N)(=O)=O)C2)C=3C=4C(N(C)C3)=CC=CC4
Relative Density.	1.48g/cm3

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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