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Phosphoribosyl pyrophosphate pentasodium
🥰Excellent
Catalog No. T38472Cas No. 108321-05-7
Alias PRPPpentasodium, PRPP pentasodium
Phosphoribosyl pyrophosphate pentasodium is the sodium salt form of PRPP. PRPP is a phosphoribosyl donor for AMP and GMP synthesis in reactions catalysed by adenine phosphoribosyltransferase and hypoxanthine/guanine phosphoribosyltransferase. PRPP is synthesized from ribose-5-phosphate and ATP by PRPP synthetase (EC 2.7.6.1).
Phosphoribosyl pyrophosphate pentasodium
🥰Excellent
Catalog No. T38472Alias PRPPpentasodium, PRPP pentasodiumCas No. 108321-05-7
Phosphoribosyl pyrophosphate pentasodium is the sodium salt form of PRPP. PRPP is a phosphoribosyl donor for AMP and GMP synthesis in reactions catalysed by adenine phosphoribosyltransferase and hypoxanthine/guanine phosphoribosyltransferase. PRPP is synthesized from ribose-5-phosphate and ATP by PRPP synthetase (EC 2.7.6.1).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $96 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Phosphoribosyl pyrophosphate pentasodium is the sodium salt form of PRPP. PRPP is a phosphoribosyl donor for AMP and GMP synthesis in reactions catalysed by adenine phosphoribosyltransferase and hypoxanthine/guanine phosphoribosyltransferase. PRPP is synthesized from ribose-5-phosphate and ATP by PRPP synthetase (EC 2.7.6.1). |
| In vitro | Phosphoribosyl diphosphate (PRPP) pentasodium serves as a crucial intermediate in cellular metabolism, synthesized via the action of PRPP synthase from ribose 5-phosphate and ATP, yielding PRPP and AMP. PRPP, ubiquitous in living organisms, participates in substitution reactions leading to glycosidic bond formation. It plays a pivotal role in the biosynthesis of purine and pyrimidine nucleotides, amino acids like histidine and tryptophan, cofactors such as NAD and tetrahydromethanopterin, arabinosyl monophosphodecaprenol, and some aminoglycoside antibiotics. Additionally, as a common substrate for adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase, PRPP pentasodium accumulates in human erythrocytes deficient in hypoxanthine-guanine phosphoribosyltransferase. The addition of 5-Phosphoribosyl-1-pyrophosphate to purified adenine phosphoribosyltransferase has been shown to enhance its stability against heat inactivation. |
| Alias | PRPPpentasodium, PRPP pentasodium |
| Molecular Weight | 499.98 |
| Formula | C5H8Na5O14P3 |
| Cas No. | 108321-05-7 |
| Smiles | O=P([O-])([O-])OP(O[C@H]1O[C@@H]([C@H]([C@H]1O)O)COP([O-])([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+] |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 40 mg/mL (80 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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