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Phosphoribosyl pyrophosphate pentasodium
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Catalog No. T38472Cas No. 108321-05-7
Alias PRPPpentasodium, PRPP pentasodium
Phosphoribosyl pyrophosphate pentasodium is the sodium salt form of PRPP. PRPP is a phosphoribosyl donor for AMP and GMP synthesis in reactions catalysed by adenine phosphoribosyltransferase and hypoxanthine/guanine phosphoribosyltransferase. PRPP is synthesized from ribose-5-phosphate and ATP by PRPP synthetase (EC 2.7.6.1).
Phosphoribosyl pyrophosphate pentasodium
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Catalog No. T38472Alias PRPPpentasodium, PRPP pentasodiumCas No. 108321-05-7
Phosphoribosyl pyrophosphate pentasodium is the sodium salt form of PRPP. PRPP is a phosphoribosyl donor for AMP and GMP synthesis in reactions catalysed by adenine phosphoribosyltransferase and hypoxanthine/guanine phosphoribosyltransferase. PRPP is synthesized from ribose-5-phosphate and ATP by PRPP synthetase (EC 2.7.6.1).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $54 | 7-10 days | 7-10 days | |
| 5 mg | Preferential | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Phosphoribosyl pyrophosphate pentasodium is the sodium salt form of PRPP. PRPP is a phosphoribosyl donor for AMP and GMP synthesis in reactions catalysed by adenine phosphoribosyltransferase and hypoxanthine/guanine phosphoribosyltransferase. PRPP is synthesized from ribose-5-phosphate and ATP by PRPP synthetase (EC 2.7.6.1). |
| In vitro | Phosphoribosyl diphosphate (PRPP) pentasodium serves as a crucial intermediate in cellular metabolism, synthesized via the action of PRPP synthase from ribose 5-phosphate and ATP, yielding PRPP and AMP. PRPP, ubiquitous in living organisms, participates in substitution reactions leading to glycosidic bond formation. It plays a pivotal role in the biosynthesis of purine and pyrimidine nucleotides, amino acids like histidine and tryptophan, cofactors such as NAD and tetrahydromethanopterin, arabinosyl monophosphodecaprenol, and some aminoglycoside antibiotics. Additionally, as a common substrate for adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase, PRPP pentasodium accumulates in human erythrocytes deficient in hypoxanthine-guanine phosphoribosyltransferase. The addition of 5-Phosphoribosyl-1-pyrophosphate to purified adenine phosphoribosyltransferase has been shown to enhance its stability against heat inactivation. |
| Synonyms | PRPPpentasodium, PRPP pentasodium |
| Molecular Weight | 499.98 |
| Formula | C5H8Na5O14P3 |
| Cas No. | 108321-05-7 |
| Smiles | O=P([O-])([O-])OP(O[C@H]1O[C@@H]([C@H]([C@H]1O)O)COP([O-])([O-])=O)([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+] |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 40 mg/mL (80 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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