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LANOSTEROL
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Catalog No. T4970Cas No. 79-63-0
Alias 8,24-Lanostadien-3β-ol, 3β-Hydroxy-8,24-lanostadiene
Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.
LANOSTEROL
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Purity: 99.67%
Catalog No. T4970Alias 8,24-Lanostadien-3β-ol, 3β-Hydroxy-8,24-lanostadieneCas No. 79-63-0
Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $53 | In Stock | In Stock | |
| 50 mg | $434 | In Stock | In Stock | |
| 100 mg | $642 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.67%
Appearance:Solid
Color:White
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Product Introduction
LANOSTEROL AI Summary
LANOSTEROL demonstrates significant bioactivity across multiple biological targets and pathways. It inhibits TPA-induced EBV-EA activation in Raji cells with increasing inhibition levels, achieving 96.3% inhibition at a 10:1 compound-to-TPA molar ratio, and shows a moderate impact on cell viability at a 1000:1 ratio with 70.0% activity. LANOSTEROL has a Km value of 30000.0 nM for human reconstituted CYP51 binding and exhibits bioactivity against Phytophthora cactorum growth, reducing colony diameter to 30.5 mm at 10 mg/L over 6 days. It binds to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme B and Candida albicans CYP51 with dissociation constants of 8.6 uM, 3.1 uM, and a Km value of 7400.0 nM, respectively.
In Mycobacterium tuberculosis, it shows activity with CYP125A1 and CYP142A1 enzymes, with Kcat(app) values of 10.37 /min and 22.09 /min and relative apparent activities of 37.0% and 132.3% compared to cholesterol. As a PPARalpha agonist, its potency is 12589.3 nM. LANOSTEROL inhibits sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells, with inhibition rates of 53.97% and 90.91% at 10 µM.
Additionally, it exhibits hepatoprotective activity against D-galactosamine-induced toxicity in rat WB-F344 cells, showing 74.8% inhibition and enhancing cell survival to 92.0% at 10 uM. LANOSTEROL shows antiausteritic activity against human PANC1 cells in nutrient-deprived medium with a PC50 value of 68.7 uM, and it inhibits alpha-crystallin B R120G mutant-induced protein aggregation in human HeLa or HLE-B3 cells with an EC50 of 1420.0 nM.
Finally, it acts as a substrate for Naegleria fowleri CYP51 expressed in E. coli, with a Kcat/Km value of 1.3 microM/min, a Km value of 48000.0 nM, a Kcat value of 64.0 /min, and a dissociation constant (Kd) of 28.0 nM. Collectively, these activities make LANOSTEROL a promising candidate for diverse therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived. |
| Synonyms | 8,24-Lanostadien-3β-ol, 3β-Hydroxy-8,24-lanostadiene |
| Molecular Weight | 426.72 |
| Formula | C30H50O |
| Cas No. | 79-63-0 |
| Smiles | [H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@]1([H])CC3)[C@H](C)CCC=C(C)C |
| Relative Density. | 0.98g/cm3 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Ethanol: 10 mM, Sonication is recommended. DMSO: Insoluble | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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