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Dehydroevodiamine

Name: Dehydroevodiamine
Brand: TargetMol
SKU: T2S2335
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S2335Cas No. 67909-49-3

Alias DHED

Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.

Dehydroevodiamine

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Purity: 99.54%

Catalog No. T2S2335Alias DHEDCas No. 67909-49-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$77	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$166	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Dehydroevodiamine AI Summary

Dehydroevodiamine is a bioactive molecule known for its diverse pharmacological properties. It acts as an inhibitor of Cytochrome P450 enzymes with varying potencies: it has a moderate inhibitory effect on Cytochrome P450 1A1 (IC50 = 18050.0 nM), a stronger inhibition on Cytochrome P450 1A2 (IC50 = 5630.0 nM), and potent inhibition on Cytochrome P450 1B1 (IC50 = 330.0 nM), displaying higher selectivity towards P450 1B1. Additionally, Dehydroevodiamine demonstrates vasodilatory effects in rat thoracic aortic rings by inhibiting phenylephrine-induced contractions, with an EC50 range of 1600.0 nM to 7780.0 nM, depending on the experimental conditions. It also acts as an antagonist at the alpha-adrenoceptor with a dissociation constant (Kd) of 128.82 nM and can displace [3H]prazosin from the alpha1 adrenoceptor with a Ki of 2400.0 nM. The compound can displace [3H]8-OH-DPAT from the 5HT1A receptor with a K_i of 36000.0 nM. Its antiinflammatory activity is evident in IFN-gamma/LPS-stimulated mouse RAW264.7 cells, where it inhibits NO production, particularly when pre-treatment occurs before IFN-gamma stimulation. The antiinflammatory effects are dose-dependent, showing significant inhibition at 10 μM and retaining activity post-LPS addition, though less effectively than pre-stimulation treatment..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities.
Synonyms	DHED

Chemical Properties

Molecular Weight	301.34
Formula	C₁₉H₁₅N₃O
Cas No.	67909-49-3
Smiles	C[n+]1c2-c3[n-]c4ccccc4c3CCn2c(=O)c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (55.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 1 mg/mL (3.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3185 mL	16.5926 mL	33.1851 mL	165.9255 mL
5 mM	0.6637 mL	3.3185 mL	6.6370 mL	33.1851 mL
10 mM	0.3319 mL	1.6593 mL	3.3185 mL	16.5926 mL
20 mM	0.1659 mL	0.8296 mL	1.6593 mL	8.2963 mL
50 mM	0.0664 mL	0.3319 mL	0.6637 mL	3.3185 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc