Anti-Caspase-8 Polyclonal Antibody

Name: Anti-Caspase-8 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00290
Rating: 4.5 (1 reviews)

(Synonyms: MORT1-associated ced-3 homolog (MACH), MCH5, ICE-like apoptotic protease 5, FADD-like ICE (FLICE), FADD-homologous ICE/ced-3-like protease, Caspase-8, CASP-8, CASP8, CAP4, Apoptotic protease Mch-5, Apoptotic cysteine protease) Copy Product Info

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Synonyms: MORT1-associated ced-3 homolog (MACH), MCH5, ICE-like apoptotic protease 5, FADD-like ICE (FLICE), FADD-homologous ICE/ced-3-like protease, Caspase-8, CASP-8, CASP8, CAP4, Apoptotic protease Mch-5, Apoptotic cysteine protease

Catalog No. TMAB-00290 Copy Product Info

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Anti-Caspase-8 Polyclonal Antibody is a Rabbit antibody targeting Caspase-8. Anti-Caspase-8 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB.

Anti-Caspase-8 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-Caspase-8 Polyclonal Antibody is a Rabbit antibody targeting Caspase-8. Anti-Caspase-8 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P, WB.
Synonyms	MORT1-associated ced-3 homolog (MACH), MCH5, ICE-like apoptotic protease 5, FADD-like ICE (FLICE), FADD-homologous ICE/ced-3-like protease, Caspase-8, CASP-8, CASP8, CAP4, Apoptotic protease Mch-5, Apoptotic cysteine protease
Ig Type	IgG
Reactivity	Human,Rat (predicted:Mouse,Dog,Pig,Cow,Horse)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	FCM=1 μg/Test; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-2000
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm.
Tissue Specificity	Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: rat Caspase-8 subunit p10
Antigen Species	Rat
Gene Name	CASP8
Gene ID	54474
Protein Name	Caspase-8
Uniprot ID	Q9JHX4
Biology Area	Caspases,Metabolism,Necroptosis,Caspases,Caspases,Other proteases,Apoptosis
Function	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.