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Fezagepras

Name: Fezagepras
Brand: TargetMol
SKU: T12883
Price: 369 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12883Cas No. 1002101-19-0

Alias Setogepram, PBI-4050

Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.

Fezagepras

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Purity: 99.38%

Catalog No. T12883Alias Setogepram, PBI-4050Cas No. 1002101-19-0

Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.

Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$68	In Stock
5 mg	$97	In Stock
10 mg	$143	In Stock
25 mg	$258	In Stock
50 mg	$369	In Stock
100 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock

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Batch Information

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Purity:99.38%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.
In vitro	TGF-β (10 ng/mL)-activated human hepatic stellate cells (HSCs) proliferation inhibited by Setogepram (PBI-4050; 500 μM; 24 hours). Setogepram (PBI-4050; 250 or 500 μM; 24hours) dose-dependently arrests HSCs at the G0/G1 phase without inducing apoptosis [2].
In vivo	In type 2 diabetes eNOS-/-db/db mice, Setogepram (PBI-4050; 100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improve glucose tolerance [1].
Synonyms	Setogepram, PBI-4050

Chemical Properties

Molecular Weight	206.28
Formula	C₁₃H₁₈O₂
Cas No.	1002101-19-0
Smiles	CCCCCc1cccc(CC(O)=O)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (290.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8478 mL	24.2389 mL	48.4778 mL	242.3890 mL
5 mM	0.9696 mL	4.8478 mL	9.6956 mL	48.4778 mL
10 mM	0.4848 mL	2.4239 mL	4.8478 mL	24.2389 mL
20 mM	0.2424 mL	1.2119 mL	2.4239 mL	12.1194 mL
50 mM	0.0970 mL	0.4848 mL	0.9696 mL	4.8478 mL
100 mM	0.0485 mL	0.2424 mL	0.4848 mL	2.4239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc