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Anti-KDM6B Polyclonal Antibody
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Catalog No. TMAB-01016
Alias Lysine-specific demethylase 6B, Lysine demethylase 6B, KIAA0346, KDM6B, Jumonji domain-containing protein 3, JMJD3, JmjC domain-containing protein 3, [histone H3]-trimethyl-L-lysine(27) demethylase 6B
Anti-KDM6B Polyclonal Antibody is a Rabbit antibody targeting KDM6B. Anti-KDM6B Polyclonal Antibody can be used in WB.
Anti-KDM6B Polyclonal Antibody
Anti-KDM6B Polyclonal Antibody
😃Good
Catalog No. TMAB-01016Alias Lysine-specific demethylase 6B, Lysine demethylase 6B, KIAA0346, KDM6B, Jumonji domain-containing protein 3, JMJD3, JmjC domain-containing protein 3, [histone H3]-trimethyl-L-lysine(27) demethylase 6B
Anti-KDM6B Polyclonal Antibody is a Rabbit antibody targeting KDM6B. Anti-KDM6B Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-KDM6B Polyclonal Antibody is a Rabbit antibody targeting KDM6B. Anti-KDM6B Polyclonal Antibody can be used in WB. |
| Synonyms | Lysine-specific demethylase 6B, Lysine demethylase 6B, KIAA0346, KDM6B, Jumonji domain-containing protein 3, JMJD3, JmjC domain-containing protein 3, [histone H3]-trimethyl-L-lysine(27) demethylase 6B |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Pig,Cow,Horse,Rabbit,Sheep) |
| Verified Activity | 1. Sample: Cerebellum (Rat) Tissue Lysate at 40 μg Primary: Anti-kDaM6b (TMAB-01016) at 1:300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1:20000 dilution Predicted band size: 177 kDa Observed band size: 177 kDa 2. Sample: Cerebellum (Rat) Lysate at 40 μg Primary: Anti-kDaM6B (TMAB-01016) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 177 kDa Observed band size: 177 kDa   |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| Concentration | 1 mg/mL |
| Research Background | JMJD3 is a 1,679 amino acid nuclear protein that contains one JmjC domain and belongs to the highly conserved JmjC domain-containing protein family. Functioning as a histone demethylase, JMJD3 uses iron and ascorbate as cofactors to demethylate dimethylated and trimethylated Lys-27 residues of Histone H3, thereby playing an important role in the modification of the histone code. Additionally, JMJD3 regulates posterior development and is involved in the inflammatory response, specifically by mediating macrophage differentiation. JMJD3 is also thought to control the expression of neurogenesis-related proteins and, via this regulatory mechanism, may be necessary for neural commitment during early development. Two isoforms of JMJD3 exist due to alternative splicing events. |
| Immunogen | KLH conjugated synthetic peptide: human KDM6B |
| Antigen Species | Human |
| Gene Name | KDM6B |
| Gene ID | |
| Protein Name | Lysine-specific demethylase 6B |
| Uniprot ID | |
| Biology Area | Jumonji containing proteins,HOX |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. |
| Molecular Weight | Theoretical: 177 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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