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Anti-BLNK Antibody (2N453)
😃Good
Catalog No. TMAY-02407
Alias SLP-65, SLP65, LY57, BLNK-S, B-cell linker, bca, BASH, AGM4
Anti-BLNK Antibody (2N453) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2N453) can be used in ELISA.
Anti-BLNK Antibody (2N453)
Anti-BLNK Antibody (2N453)
😃Good
Catalog No. TMAY-02407Alias SLP-65, SLP65, LY57, BLNK-S, B-cell linker, bca, BASH, AGM4
Anti-BLNK Antibody (2N453) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2N453) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-BLNK Antibody (2N453) is a Rabbit antibody targeting BLNK. Anti-BLNK Antibody (2N453) can be used in ELISA. |
| Alias | SLP-65, SLP65, LY57, BLNK-S, B-cell linker, bca, BASH, AGM4 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2N453 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human BLNK / Ly-57 / SLP-65 (rh BLNK / Ly-57 / SLP-65; TMPY-02191; AAH18906.1; Met 1-Ser 456). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. BLNK functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. BLNK plays a role in the activation of ERK / EPHB2, MAP kinase p38 and JNK. BLNK modulates AP1 activation. It is important for the activation of NF-kappa-B and NFAT. BLNK plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+mobilization and is required for trafficking of the BCR to late endosomes. BLNK may be required for the RAC1-JNK pathway. It plays a critical role in orchestrating the pro-B cell to pre-B cell transition. BLNK also plays an important role in BCR-induced B-cell apoptosis.Defects in BLNK are the cause of agammaglobulinemia type 4 (AGM4) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human BLNK / Ly-57 / SLP-65 protein (TMPY-02191) |
| Antigen Species | Human |
| Biology Area | Adaptor Proteins |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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