Anti-IL-27beta Antibody (7X962) is a Rabbit antibody targeting IL-27beta. Anti-IL-27beta Antibody (7X962) can be used in WB.

IgG

7X962

Human,Mouse,Rat

Western blot analysis of K562 cell lysate. Using IL-27beta (TMAB-07646) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

WB: 1:1000-2000

Monoclonal

A synthesized peptide: human IL 27B

Human

EBI3

Interleukin-27 subunit beta

Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.