Shopping Cart

Your shopping cart is currently empty

Gigantol

Name: Gigantol
Brand: TargetMol
SKU: TN7033
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. TN7033Cas No. 83088-28-2

Alias 3,4'-dihydroxy-5,5'-dimethoxybibenzyl

Gigantol(Dendrophenol) (3,4'-dihydroxy-5,5'-dimethoxybibenzyl) is isolated from the stems of Dendrobium candidum.

Gigantol

Copy Product Info

😃Good

Purity: 99.96%

Catalog No. TN7033Alias 3,4'-dihydroxy-5,5'-dimethoxybibenzylCas No. 83088-28-2

Gigantol(Dendrophenol) (3,4'-dihydroxy-5,5'-dimethoxybibenzyl) is isolated from the stems of Dendrobium candidum.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$87	-	In Stock
5 mg	$213	-	In Stock
10 mg	$339	-	In Stock
25 mg	$566	-	In Stock
50 mg	$791	-	In Stock
100 mg	$1,090	-	In Stock
500 mg	$2,190	-	In Stock
1 mL x 10 mM (in DMSO)	$207	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Color:Transparent to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Gigantol AI Summary

Gigantol demonstrates a diverse range of biological activities including antioxidant, anti-inflammatory, spasmolytic, cytotoxic, antifungal, antiproliferative, and enzyme inhibitory effects. It exhibits antioxidant activity with an IC50 of 56400.0 nM in a DPPH radical scavenging assay. The compound shows anti-inflammatory effects by inhibiting nitric oxide (NO) production in LPS and TNF-alpha activated murine RAW 264.7 cells (IC50 of 32900.0 nM) and inhibiting superoxide anion generation (IC50 of 2100.0 nM) and elastase release (IC50 of 3200.0 nM) in human neutrophils. Moreover, it demonstrates spasmolytic activity with an IC50 of 260.0 nM in the guinea pig ileum and also inhibits bovine brain CaM-dependent PDE with an IC50 of 7000.0 nM. In cytotoxicity assays, it is active against several human cancer cell lines, including HepG2 (IC50 of 1883.0 nM) and HCCLM3 (IC50 of 57900.0 nM), as well as human NCI-H460 cells. The compound also affects cell migration and shows significant inhibition in wound healing and Boyden chamber assays. Additionally, Gigantol displays antifungal activity against multiple fungi strains with MIC values ranging from 91200.0 nM to 365000.0 nM. It also has enzyme inhibitory effects, shown by its inhibition of pyruvate carboxylase in HCCLM3 cell lysate (IC50 of 125.0 nM), alpha-glucosidase, PTP1B, and aldose reductase with various IC50 values. Finally, it demonstrates considerable inhibitory effects on calmodulin-dependent PDE1 activity (IC50 of 114180.0 nM) and has antiproliferative activity against multiple cancer cells including HeLa, MCF7, and A549 with IC50 values greater than 10000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Gigantol(Dendrophenol) (3,4'-dihydroxy-5,5'-dimethoxybibenzyl) is isolated from the stems of Dendrobium candidum.
Synonyms	3,4'-dihydroxy-5,5'-dimethoxybibenzyl

Chemical Properties

Molecular Weight	274.31
Formula	C₁₆H₁₈O₄
Cas No.	83088-28-2
Smiles	C(CC1=CC(OC)=C(O)C=C1)C2=CC(OC)=CC(O)=C2
Relative Density.	1.204 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 72.5 mg/mL (264.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6455 mL	18.2276 mL	36.4551 mL	182.2755 mL
5 mM	0.7291 mL	3.6455 mL	7.2910 mL	36.4551 mL
10 mM	0.3646 mL	1.8228 mL	3.6455 mL	18.2276 mL
20 mM	0.1823 mL	0.9114 mL	1.8228 mL	9.1138 mL
50 mM	0.0729 mL	0.3646 mL	0.7291 mL	3.6455 mL
100 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8228 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc