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Anti-Alpha 2 Macroglobulin Antibody (5H848)
😃Good
Catalog No. TMAB-02458
Anti-Alpha 2 Macroglobulin Antibody (5H848) is a Mouse antibody targeting Alpha 2 Macroglobulin. Anti-Alpha 2 Macroglobulin Antibody (5H848) can be used in WB.
Anti-Alpha 2 Macroglobulin Antibody (5H848)
Anti-Alpha 2 Macroglobulin Antibody (5H848)
😃Good
Catalog No. TMAB-02458
Anti-Alpha 2 Macroglobulin Antibody (5H848) is a Mouse antibody targeting Alpha 2 Macroglobulin. Anti-Alpha 2 Macroglobulin Antibody (5H848) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Alpha 2 Macroglobulin Antibody (5H848) is a Mouse antibody targeting Alpha 2 Macroglobulin. Anti-Alpha 2 Macroglobulin Antibody (5H848) can be used in WB. |
| Ig Type | IgG2a, Kappa |
| Clone | 5H848 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Secreted |
| Tissue Specificity | Secreted in plasma |
| Construction | Recombinant Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human Alpha 2 Macroglobulin |
| Antigen Species | Human |
| Gene Name | A2M |
| Gene ID | |
| Protein Name | alpha-2-macroglobulin |
| Uniprot ID | |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Molecular Weight | Theoretical: 160 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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