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Enmein
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Catalog No. TN1144Cas No. 3776-39-4
Enmein shows a significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 μg/ml to 8.2 μg/ml.
Enmein
😃Good
Catalog No. TN1144Cas No. 3776-39-4
Enmein shows a significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 μg/ml to 8.2 μg/ml.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $628 | Backorder | |
| 5 mg | $1,752 | Backorder | |
| 10 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Enmein shows a significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 μg/ml to 8.2 μg/ml. |
| In vitro | Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodosin (6), epi-nodosinol (7), Enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some diterpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. |
| Molecular Weight | 362.42 |
| Formula | C20H26O6 |
| Cas No. | 3776-39-4 |
| Smiles | CC1(C)[C@@H](O)C[C@H]2[C@@]3([C@@H]4CC[C@@H]5C[C@@]4(C(O2)=O)C(C5=C)=O)[C@@H]1[C@H](O)OC3 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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