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Clinofibrate

Name: Clinofibrate
Brand: TargetMol
SKU: T6450
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6450Cas No. 30299-08-2

Alias S-8527, Lipoclin

Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.

Clinofibrate

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Purity: 99.50%

Catalog No. T6450Alias S-8527, LipoclinCas No. 30299-08-2

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$48	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.50%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
Targets&IC50	HMG-CoA reductase:0.47 mM
In vitro	In the treatment of arteriosclerosis in rats, Clinofibrate significantly reduces high plasma cholesterol levels. When used in CAPD patients, it effectively decreases very low-density lipoprotein levels. Typically, Clinofibrate (600 mg/daily) reduces serum triglycerides by 36% and very low-density lipoprotein triglycerides by 48%. Additionally, it ameliorates abnormalities in low-density and high-density lipoprotein compositions, markedly increasing the content of high-density lipoprotein cholesterol.
In vivo	Clinofibrate, with an IC50 of 40 μM, acts on the activity of human liver 3α-hydroxysteroid dehydrogenase.
Synonyms	S-8527, Lipoclin

Chemical Properties

Molecular Weight	468.58
Formula	C₂₈H₃₆O₆
Cas No.	30299-08-2
Smiles	O(C(C(O)=O)(CC)C)C1=CC=C(C2(CCCCC2)C3=CC=C(OC(C(O)=O)(CC)C)C=C3)C=C1
Relative Density.	1.1005 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 87 mg/mL (185.67 mM), Sonication is recommended.

Ethanol: 87 mg/mL (185.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.1341 mL	10.6705 mL	21.3411 mL	106.7054 mL
5 mM	0.4268 mL	2.1341 mL	4.2682 mL	21.3411 mL
10 mM	0.2134 mL	1.0671 mL	2.1341 mL	10.6705 mL
20 mM	0.1067 mL	0.5335 mL	1.0671 mL	5.3353 mL
50 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1341 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	1.0671 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc