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Anti-IL-23 Antibody (8I736)
😃Good
Catalog No. TMAB-07640
Anti-IL-23 Antibody (8I736) is a Rabbit antibody targeting IL-23. Anti-IL-23 Antibody (8I736) can be used in WB.
Anti-IL-23 Antibody (8I736)
Anti-IL-23 Antibody (8I736)
😃Good
Catalog No. TMAB-07640
Anti-IL-23 Antibody (8I736) is a Rabbit antibody targeting IL-23. Anti-IL-23 Antibody (8I736) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-IL-23 Antibody (8I736) is a Rabbit antibody targeting IL-23. Anti-IL-23 Antibody (8I736) can be used in WB. |
| Ig Type | IgG |
| Clone | 8I736 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. Secreted upon association with IL12B. |
| Tissue Specificity | Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity.Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. |
| Immunogen | A synthesized peptide: human IL 23A |
| Antigen Species | Human |
| Gene Name | Il23a |
| Gene ID | |
| Protein Name | Interleukin-23 subunit alpha |
| Uniprot ID | |
| Function | Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Molecular Weight | Theoretical: 21 kDa. Actual: 21 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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