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GPNA hydrochloride

🥰Excellent
Catalog No. T15411Cas No. 67953-08-6

GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.

GPNA hydrochloride

GPNA hydrochloride

🥰Excellent
Purity: 99.13%
Catalog No. T15411Cas No. 67953-08-6
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.
Pack SizePriceAvailabilityQuantity
10 mg$31In Stock
25 mg$61In Stock
50 mg$106In Stock
100 mg$147In Stock
500 mg$368In Stock
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Purity:99.13%
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Product Introduction

Bioactivity
Description
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.
In vitro
GPNA hydrochloride is a glutamine transporter ASCT2 inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers.
Chemical Properties
Molecular Weight303.7
FormulaC11H14ClN3O5
Cas No.67953-08-6
SmilesCl.NC(=O)CCC(Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 124 mg/mL (408.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2927 mL16.4636 mL32.9272 mL164.6362 mL
5 mM0.6585 mL3.2927 mL6.5854 mL32.9272 mL
10 mM0.3293 mL1.6464 mL3.2927 mL16.4636 mL
20 mM0.1646 mL0.8232 mL1.6464 mL8.2318 mL
50 mM0.0659 mL0.3293 mL0.6585 mL3.2927 mL
100 mM0.0329 mL0.1646 mL0.3293 mL1.6464 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

γ-glutamyltransferasetransporterSNATlungLATInhibitorinhibitGPNA hydrochlorideGPNA HydrochlorideGPNAglutamineGlnGGTASCT2ApoptosisA549
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