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8-Azaadenosine

Name: 8-Azaadenosine
Brand: TargetMol
SKU: T9111
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9111Cas No. 10299-44-2

8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

8-Azaadenosine

🥰Excellent

Purity: 99.39%

Catalog No. T9111Cas No. 10299-44-2

8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$80	In Stock
10 mg	$122	In Stock
25 mg	$272	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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Batch Information

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Purity:99.39%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

In vitro

8-azaadenosine (8-aza-AR) was a potent inhibitor of purine synthesis de novo, but 8-aza-HR, at concentrations much higher than the inhibitory concentration of 8-aza-AR, did not inhibit this process.?In H. Ep. 2 cells, 8-aza-HR blocked the conversion of orotic acid to uridine nucleotides and caused an accumulation of orotidine.?This inhibition of pyrimidine biosynthesis apparently does not contribute significantly to the cytotoxicity of 8-aza-HR because uridine provided no degree of reversal of its inhibition of the growth of cell cultures.

Chemical Properties

Molecular Weight	268.23
Formula	C₉H₁₂N₆O₄
Cas No.	10299-44-2
Smiles	Nc1ncnc2n(nnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Relative Density.	2.29 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (932.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7281 mL	18.6407 mL	37.2814 mL	186.4072 mL
5 mM	0.7456 mL	3.7281 mL	7.4563 mL	37.2814 mL
10 mM	0.3728 mL	1.8641 mL	3.7281 mL	18.6407 mL
20 mM	0.1864 mL	0.9320 mL	1.8641 mL	9.3204 mL
50 mM	0.0746 mL	0.3728 mL	0.7456 mL	3.7281 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8641 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc