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Isorhamnetin-3-O-neohespeidoside
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Catalog No. T3799Cas No. 55033-90-4
Alias Isorhamnetin 3-O-neohesperoside, Isorhamnetin 3-O-neohesperidin, Calendoflavoside
Isorhamnetin-3-O-neohespeidoside (Calendoflavoside) is a flavonol glycoside extract used as an anti-oxidant.
Isorhamnetin-3-O-neohespeidoside
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Purity: 99.44%
Catalog No. T3799Alias Isorhamnetin 3-O-neohesperoside, Isorhamnetin 3-O-neohesperidin, CalendoflavosideCas No. 55033-90-4
Isorhamnetin-3-O-neohespeidoside (Calendoflavoside) is a flavonol glycoside extract used as an anti-oxidant.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $46 | In Stock | In Stock | |
| 10 mg | $63 | In Stock | In Stock | |
| 25 mg | $98 | In Stock | In Stock | |
| 50 mg | $147 | In Stock | In Stock | |
| 100 mg | $215 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $61 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.44%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Isorhamnetin-3-O-neohespeidoside AI Summary
Isorhamnetin-3-O-neohespeidoside exhibits significant inhibitory activity against TPA-induced EBV-early antigen activation in human Raji cells, with notable effectiveness at a molar ratio of 10 relative to TPA and an IC50 value of 574.0 molar ratio. However, the compound also shows cytotoxicity in these cells, with activities exceeding 80.0% at various molar ratios, suggesting a potential risk to cell viability. Additionally, Isorhamnetin-3-O-neohespeidoside demonstrates estrogenic activity at ERalpha in human MVLN cells, where it achieved 55.77% activity relative to E2 at 100 ug/mL after 24 hours, and 88.3% activity at 20 ug/mL within the same time frame. The compound further shows varying degrees of cytotoxic effects across different cell lines: human Bel7402 and HCT116 cells with IC50 values of 74400.0 nM and 72000.0 nM, respectively; potent cytotoxicity in human T47D cells with an IC50 value of 0.003 ug/mL after 48 hours; moderate effects in human Caco2 cells with an IC50 of 2.47 ug/mL; and relatively low cytotoxicity in mouse NIH/3T3 cells, with IC50 greater than 200.0 ug/mL after 96 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Isorhamnetin-3-O-neohespeidoside (Calendoflavoside) is a flavonol glycoside extract used as an anti-oxidant. |
| Synonyms | Isorhamnetin 3-O-neohesperoside, Isorhamnetin 3-O-neohesperidin, Calendoflavoside |
| Molecular Weight | 624.54 |
| Formula | C28H32O16 |
| Cas No. | 55033-90-4 |
| Smiles | COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O |
| Relative Density. | 1.74 g/cm3 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (400.29 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.2 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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