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Anti-MEK5 Antibody (4P780) is a Rabbit antibody targeting MEK5. Anti-MEK5 Antibody (4P780) can be used in WB,ICC/IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $497 | 7-10 days |
Description | Anti-MEK5 Antibody (4P780) is a Rabbit antibody targeting MEK5. Anti-MEK5 Antibody (4P780) can be used in WB,ICC/IF. |
Synonyms | SKK5, SAPKK5, Protein kinase, mitogen-activated, kinase 5, PRKMK5, MP2K5_HUMAN, MKK5, mitogen-activated protein kinase kinase 5, MEK 5, MAPKK5, MAPKK 5, MAPK/ERK kinase 5, MAP2K5, MAP kinase kinase MEK5b, MAP kinase kinase 5, HsT17454, EC 2.7.12.2, Dual specificity mitogen-activated protein kinase kinase 5, Dual specificity mitogen activated protein kinase kinase 5 |
Ig Type | IgG |
Clone | 4P780 |
Reactivity | Human |
Verified Activity | 1. Western blot analysis of MEK5 on Hela cells lysates using anti-MEK5 antibody at 1/1,000 dilution. 2. ICC staining MEK5 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining MEK5 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining MEK5 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
Application | |
Recommended Dose | WB: 1:1000-5000; ICC/IF: 1:50-200 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Recombinant Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Molecular Weight | Theoretical: 49 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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