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Gramicidin A

Name: Gramicidin A
Brand: TargetMol
SKU: T36439
Rating: 4.5 (1 reviews)

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Catalog No. T36439Cas No. 11029-61-1

Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities.

Gramicidin A

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Catalog No. T36439Cas No. 11029-61-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	35 days	35 days
5 mg	$362	35 days	35 days
10 mg	$667	35 days	35 days
25 mg	$1,380	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities.
Targets&IC50	Caki-1 cells:0.228 μM, 786-O cells:0.430 μM, A498 cells:0.420 μM, SN12C:0.104 μM, ACHN cells:0.783
In vitro	Gramicidin A (0.1 nM-10 μM; 72 h) reduces the viability of RCC cell lines and affects cell viability comparable to Monensin.[2] Gramicidin A (1 and 10 μM, 48 or 72 h) induces nonapoptotic cell death in RCC cells.[2] Gramicidin A (0-10 μM, 24 h) depletes cellular energy and induces metabolic dysfunction in RCC cells.[2] Gramicidin A (0-1 μM, 24-72 h) reduces HIF-1α and HIF-2α protein expression and reduces HIF transcriptional activity and target gene expression (24 h).[3]
In vivo	Gramicidin A (0.11 mg/kg; intratumoral injection; 2 weeks; 14 days) inhibits the growth of RCC tumor xenografts with an average tumor mass reduction of approximately 40% without significant toxicity.[2] Gramicidin A (0.22 mg/kg; intratumoral injection; 3 weeks; 26 days) inhibits the growth and angiogenesis of VHL-expressing RCC tumor xenografts.[3]

Chemical Properties

Molecular Weight	1882.29
Formula	C₉₉H₁₄₀N₂₀O₁₇
Cas No.	11029-61-1
Smiles	CC(C)CC(NC(=O)C(C)NC(=O)CNC(=O)C(NC=O)C(C)C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCO
Sequence	For-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-Gly-ol
Sequence Short	VGALAVVVWLWLWLWG

Storage & Solubility Information

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble H2O: Slightly soluble Ethanol: Soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc