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Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody

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Catalog No. TMAB-01509

Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT3 (Tyr705). Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody can be used in WB.

Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody

Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody

😃Good
Catalog No. TMAB-01509
Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT3 (Tyr705). Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$221 7-10 days
100 μL$372 7-10 days
200 μL$527 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT3 (Tyr705). Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse,Rat
Verified Activity
25 μg total protein per Lane of various lysates probed with phospho-STAT3 (Tyr705) polyclonal antibody, unconjugated (TMAB-01509) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human STAT3 around the phosphorylation site of Tyr705
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
STAT family,Transcription factors/regulators,Transcription factors,Surface molecules,STATs,Other factors,SARS Coronavirus,STATs,Intracellular
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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