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Taccalonolide A

🥰Excellent
Catalog No. TN2254Cas No. 108885-68-3

Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

Taccalonolide A

Taccalonolide A

🥰Excellent
Purity: 99.4%
Catalog No. TN2254Cas No. 108885-68-3
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$110In Stock
10 mg$158In Stock
1 mL x 10 mM (in DMSO)$165In Stock
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Purity:99.4%
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Product Introduction

Bioactivity
Description
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.
Chemical Properties
Molecular Weight702.74
FormulaC36H46O14
Cas No.108885-68-3
Smiles[H][C@@]12[C@H](OC(C)=O)[C@@]3([H])[C@]4([H])[C@@H](O)C(=O)[C@@]5([H])C[C@@H]6O[C@@H]6[C@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(C)[C@@]1([H])[C@H](C)C=C1OC(=O)[C@@](C)(O)[C@]21C
Relative Density.1.41 g/cm3 at 20℃
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (85.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4230 mL7.1150 mL14.2300 mL71.1501 mL
5 mM0.2846 mL1.4230 mL2.8460 mL14.2300 mL
10 mM0.1423 mL0.7115 mL1.4230 mL7.1150 mL
20 mM0.0712 mL0.3558 mL0.7115 mL3.5575 mL
50 mM0.0285 mL0.1423 mL0.2846 mL1.4230 mL

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Keywords

Taccalonolide AP-gpMicrotubuleAssociatedMicrotubule/TubulinMicrotubule AssociatedmicrotubuleInhibitorinhibitCaspaseBcl-2Apoptosis
Related Tags: buy Taccalonolide A | purchase Taccalonolide A | Taccalonolide A cost | order Taccalonolide A | Taccalonolide A chemical structure | Taccalonolide A formula | Taccalonolide A molecular weight
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