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Taccalonolide A

Name: Taccalonolide A
Brand: TargetMol
SKU: TN2254
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TN2254 Copy Product Info

Purity: 99.4%

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Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

Taccalonolide A

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Catalog No. TN2254

Cas No. 108885-68-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$48	In Stock	In Stock
5 mg	$110	In Stock	In Stock
10 mg	$158	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$165	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.4%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	702.74
Formula	C₃₆H₄₆O₁₄
Cas No.	108885-68-3
Smiles	[H][C@@]12[C@H](OC(C)=O)[C@@]3([H])[C@]4([H])[C@@H](O)C(=O)[C@@]5([H])C[C@@H]6O[C@@H]6[C@H](OC(C)=O)[C@]5(C)[C@@]4([H])[C@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(C)[C@@]1([H])[C@H](C)C=C1OC(=O)[C@@](C)(O)[C@]21C
Relative Density.	1.41 g/cm3 at 20℃

Storage & Solubility Information

Storage

Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (85.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4230 mL	7.1150 mL	14.2300 mL	71.1501 mL
5 mM	0.2846 mL	1.4230 mL	2.8460 mL	14.2300 mL
10 mM	0.1423 mL	0.7115 mL	1.4230 mL	7.1150 mL
20 mM	0.0712 mL	0.3558 mL	0.7115 mL	3.5575 mL
50 mM	0.0285 mL	0.1423 mL	0.2846 mL	1.4230 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc