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Oxacillin sodium salt

Name: Oxacillin sodium salt
Brand: TargetMol
SKU: T0985
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0985Cas No. 1173-88-2

Alias Oxacillin sodium, Oxabel sodium salt

Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.

Oxacillin sodium salt

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Purity: 99.93%

Catalog No. T0985Alias Oxacillin sodium, Oxabel sodium saltCas No. 1173-88-2

Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$39	In Stock	In Stock
200 mg	$55	In Stock	In Stock
500 mg	$90	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Oxacillin sodium salt AI Summary

Oxacillin sodium salt exhibits a broad range of bioactivities, including significant antibacterial and antiviral properties. It demonstrates potent activity as an inhibitor of beta-lactamase in Enterobacter aerogenes, with a high relative inhibition value of 5000.0 compared to oxacillin sulfoxide, and shows efficacy against methicillin-resistant Staphylococcus aureus (MRSA) with MIC values as low as 0.25 ug/mL. Additionally, MIC values against other bacterial strains vary widely, from highly potent (≤ 0.39 ug/mL against Staphylococcus aureus) to less effective (> 128.0 ug/mL against certain penicillin-resistant strains). In pharmacokinetic studies, the compound reaches a concentration of 41.1 ug/mL in rat blood within 3 minutes and displays varied absorption rates in rabbit blood (15.3 ug/mL after 5 minutes and 9.1 ug/mL after 10 minutes). It also possesses a calculated lipophilicity with a Log k value of 1.868. In terms of antiviral activity, Oxacillin sodium salt shows inhibition of SARS-CoV-2 induced cytotoxicity in several cell lines, including VERO-6 and Caco-2 cells, although the inhibition rates are relatively low (0.08% and 3.58% respectively, at 10 uM). Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 33.68% at 20µM. Oxacillin sodium salt also impacts various biochemical pathways and targets, such as enhancing SMN2 splice variant expression with a potency of 501.2 nM, and inhibiting Aldehyde Dehydrogenase 1 (ALDH1A1) and AmpC Beta-Lactamase with potencies of 44668.4 nM and 5623.4 nM respectively. It exhibits a potent inhibitory effect on sodium fluorescein uptake in OATP1B1-transfected and OATP1B3-transfected CHO cells, with inhibition rates of 76.67% and 90.07% at 10 uM. Lastly, Oxacillin sodium salt shows low inhibitory effects on human BSEP, MRP2, MRP3, and MRP4, with IC50 values greater than 133,000.0 nM, and demonstrates minimal impact on cell viability in Vero E6 cells infected with SARS-CoV-2. It also exhibits differential inhibition of human HDAC6 activity, with various effects depending on the peptide substrates used in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.
Synonyms	Oxacillin sodium, Oxabel sodium salt

Chemical Properties

Molecular Weight	423.43
Formula	C₁₉H₁₈N₃NaO₅S
Cas No.	1173-88-2
Smiles	[Na+].Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C([O-])=O)-c1ccccc1
Relative Density.	1.49g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 128 mg/mL (302.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3617 mL	11.8083 mL	23.6167 mL	118.0833 mL
5 mM	0.4723 mL	2.3617 mL	4.7233 mL	23.6167 mL
10 mM	0.2362 mL	1.1808 mL	2.3617 mL	11.8083 mL
20 mM	0.1181 mL	0.5904 mL	1.1808 mL	5.9042 mL
50 mM	0.0472 mL	0.2362 mL	0.4723 mL	2.3617 mL
100 mM	0.0236 mL	0.1181 mL	0.2362 mL	1.1808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc