SIRT5 inhibitor 2

Name: SIRT5 inhibitor 2
Brand: TargetMol
SKU: T62032
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62032Cas No. 340306-87-8

SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with IC50=2.3 μM that has inhibitory activity through SIRT5-dependent deacetylation and can be used to study cancer and neurodegenerative diseases.

SIRT5 inhibitor 2

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Purity: 99.87%

Catalog No. T62032Cas No. 340306-87-8

Pack Size	Price	Availability
1 mg	$293	In Stock
5 mg	$722	In Stock
10 mg	$987	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock

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Purity:99.87%

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Product Introduction

Bioactivity

Description	SIRT5 inhibitor 2 (compound 49) is a potent SIRT5 inhibitor with IC50=2.3 μM that has inhibitory activity through SIRT5-dependent deacetylation and can be used to study cancer and neurodegenerative diseases.
Targets&IC50	SIRT5:2.3 μM
In vitro	SIRT5 inhibitor 2 (compound 49) is a selective inhibitor of SIRT5, showing an IC₅₀ of 2.3 μM. SIRT5 inhibitor 2 effectively blocks SIRT5-mediated desuccinylation and is applicable in studies related to cancer and neurodegenerative disorders [1].

Chemical Properties

Molecular Weight	407.27
Formula	C₁₈H₁₂Cl₂N₂O₃S
Cas No.	340306-87-8
Smiles	O=C1NC(=S)N(C(=O)C1=CC=2OC(=CC2)C=3C=CC=C(Cl)C3Cl)CC=C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc