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Anti-LIMPII/SR-B2 Antibody-APC (7J773) is a APC-conjugated Rabbit antibody targeting LIMPII/SR-B2. Anti-LIMPII/SR-B2 Antibody-APC (7J773) can be used in FCM.
Description | Anti-LIMPII/SR-B2 Antibody-APC (7J773) is a APC-conjugated Rabbit antibody targeting LIMPII/SR-B2. Anti-LIMPII/SR-B2 Antibody-APC (7J773) can be used in FCM. |
Ig Type | Monoclonal Rabbit IgG |
Clone | 7J773 |
Reactivity | Mouse |
Verified Activity | Flow cytometric analysis of Mouse SCARB2 expression in spleen lymphocytes. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with APC Rabbit anti-Mouse SCARB2. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
Application | FCM |
Recommended Dose | 10 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse LIMP-2 / SCARB2 / CD36L2 (rM LIMP-2 / SCARB2 / CD36L2; TMPY-01434; NP_031670.1; Met1-Thr432) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
Research Background | Lysosomal Integral Membrane Protein II (LIMPII), also known as SCARB2, LPG85, and CD36L2, is a type I II multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. This protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. LIMPII is identified as a receptor for EV71 (human enterovirus species A, Enterovirus 71) and CVA16 (coxsackievirus A16) which are most frequently associated with hand, foot and mouth disease (HFMD). Expression of human LIMPII enables normally unsusceptible cell lines to support the viruses’ propagation and develop cytopathic effects. In addition, LIMPII also has been shown to bind thrombospondin-1, and may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation. Deficiency of the protein in mice impairs cell membrane transport processes and causes pelvic junction obstruction, deafness, and peripheral neuropathy. |
Conjucates | APC |
Others Formats | Unconjugated/FITC/PE |
Antibody Types Available | 4 |
Immunogen | Recombinant Mouse LIMP-2 / SCARB2 / CD36L2 protein (TMPY-01434) |
Antigen Species | Mouse |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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