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5-HYDROXYINDOLE-3-ACETIC ACID

Name: 5-HYDROXYINDOLE-3-ACETIC ACID
Brand: TargetMol
SKU: T4744
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4744Cas No. 54-16-0

Alias 5-HIAA

5-Hydroxyindole-3-acetic acid (5-HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors (NCI).

5-HYDROXYINDOLE-3-ACETIC ACID

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Purity: 99.15%

Catalog No. T4744Alias 5-HIAACas No. 54-16-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.15%

Appearance:Solid

Resource Download

COA HPLC HNMR

Product Introduction

5-HYDROXYINDOLE-3-ACETIC ACID AI Summary

5-HYDROXYINDOLE-3-ACETIC ACID exhibits a log Kow value of 0.74, indicating a moderate octanol-water partition coefficient, and a logKA value of -0.125, suggesting binding affinity to human serum albumin. It shows diverse bioactivities, acting as an agonist and inhibitor in several biological pathways and processes. Notably, it is an agonist for the NFkB signaling pathway and the Thyroid Stimulating Hormone Receptor. It inhibits Plasmodium falciparum proliferation, Mycobacterium tuberculosis, ALDH1A1, HPGD, Histone Lysine Methyltransferase G9a, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), cell surface uPA generation, the Vitamin D Receptor (VDR), USP1/UAF1, and entry of Lassa and Marburg viruses. In specific cell contexts, it induces DNA re-replication and synthetic lethality in tumor cells producing 2HG. Additionally, it inhibits Indoxyl sulfate uptake in Xenopus laevis oocytes with 18.7% activity, and benzylpenicillin uptake by 5-Hydroxyindole-3-acetic acid in Oat3-expressing oocytes at 1000uM concentration with 21.7% activity. At human GPR17, it demonstrates antagonist and agonist activities, including inhibition of MDL 29,951-induced calcium mobilization with an IC50 > 30000.0 nM and an inhibition rate of 7.0% at >30 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	5-Hydroxyindole-3-acetic acid (5-HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors (NCI).
Synonyms	5-HIAA

Chemical Properties

Molecular Weight	191.18
Formula	C₁₀H₉NO₃
Cas No.	54-16-0
Smiles	OC(=O)CC1=CNC2=CC=C(O)C=C12
Relative Density.	1.496g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 81.67 mg/mL (427.19 mM), Sonication is recommended.

Ethanol: 50 mg/mL (261.53 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2307 mL	26.1534 mL	52.3067 mL	261.5336 mL
5 mM	1.0461 mL	5.2307 mL	10.4613 mL	52.3067 mL
10 mM	0.5231 mL	2.6153 mL	5.2307 mL	26.1534 mL
20 mM	0.2615 mL	1.3077 mL	2.6153 mL	13.0767 mL
50 mM	0.1046 mL	0.5231 mL	1.0461 mL	5.2307 mL
100 mM	0.0523 mL	0.2615 mL	0.5231 mL	2.6153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc