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Anti-LAG3 Antibody (5D620)
(Synonyms: lymphocyte-activation gene 3, LAG-3, CD223) Copy Product Info
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Synonyms: lymphocyte-activation gene 3, LAG-3, CD223
Catalog No. TMAH-00681 Copy Product Info
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Anti-LAG3 Antibody (5D620) is a Mouse antibody targeting LAG3. Anti-LAG3 Antibody (5D620) can be used in ELISA,FCM,IHC,WB.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $207 | 7-10 days | 7-10 days | |
| 100 μL | $348 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-LAG3 Antibody (5D620) is a Mouse antibody targeting LAG3. Anti-LAG3 Antibody (5D620) can be used in ELISA,FCM,IHC,WB. |
| Synonyms | lymphocyte-activation gene 3, LAG-3, CD223 |
| Ig Type | IgG1 |
| Clone | 5D620 |
| Reactivity | Human |
| Application | |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein.; [Secreted lymphocyte activation gene 3 protein]: Secreted. |
| Tissue Specificity | Primarily expressed in activated T-cells and a subset of natural killer (NK) cells. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear. May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Lymphocyte activation gene 3 Protein (29-450AA) |
| Antigen Species | Human |
| Gene Name | LAG3 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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