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Bucladesine calcium

Name: Bucladesine calcium
Brand: TargetMol
SKU: T63257
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63257Cas No. 938448-87-4

Alias Dibutyryl cAMP calcium salt, DBcAMP calcium salt

Bucladesine calcium (Dibutyryl cAMP calcium salt) is a cell-permeable cAMP analog and selective PKA activator that increases intracellular cAMP levels. Bucladesine calcium also functions as a phosphodiesterase (PDE) inhibitor with anti-inflammatory activity.

Bucladesine calcium

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Catalog No. T63257Alias Dibutyryl cAMP calcium salt, DBcAMP calcium saltCas No. 938448-87-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$29	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Bucladesine calcium (Dibutyryl cAMP calcium salt) is a cell-permeable cAMP analog and selective PKA activator that increases intracellular cAMP levels. Bucladesine calcium also functions as a phosphodiesterase (PDE) inhibitor with anti-inflammatory activity.
In vivo	Compared to controls, Bucladesine calcium (bilateral infusion; 10/100 mM) improved spatial memory in male rats. Infusion of 1 mM and 5 mM concentrations within minutes after 0.5 mg nicotine infusion enhanced spatial memory retention in male rats [1]. Combined administration of Bucladesine calcium (10 mM/side) with nicotine (0.5 mM/side) resulted in significantly increased ChAT and VAChT immunoreactivity in the CA1 region and reduced escape latency and travel distance in rats [2]. Bucladesine calcium (in a 1.5% emulsion; single or multiple doses) significantly reduced inflammatory edema in an arachidonic acid-induced mouse ear edema model [4].
Synonyms	Dibutyryl cAMP calcium salt, DBcAMP calcium salt

Chemical Properties

Molecular Weight	976.84
Formula	C₃₆H₄₆CaN₁₀O₁₆P₂
Cas No.	938448-87-4
Smiles	CCCC(O[C@H]1[C@H](N2C3=NC=NC(NC(CCC)=O)=C3N=C2)O[C@@]4([H])[C@@]1([H])OP([O-])(OC4)=O)=O.CCCC(O[C@H]5[C@H](N6C7=NC=NC(NC(CCC)=O)=C7N=C6)O[C@@]8([H])[C@@]5([H])OP([O-])(OC8)=O)=O.[Ca+2]

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80.00 mg/mL (81.90 mM), Sonication is recommended.

DMSO: 80.00 mg/mL (81.90 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0237 mL	5.1185 mL	10.2371 mL	51.1855 mL
5 mM	0.2047 mL	1.0237 mL	2.0474 mL	10.2371 mL
10 mM	0.1024 mL	0.5119 mL	1.0237 mL	5.1185 mL
20 mM	0.0512 mL	0.2559 mL	0.5119 mL	2.5593 mL
50 mM	0.0205 mL	0.1024 mL	0.2047 mL	1.0237 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc